Response to letter regarding article: Developing DCE-CT to quantify intra-tumor heterogeneity in breast tumors with differing angiogenic phenotype

Minsong Cao, Yun Liang, Keith M. Stantz

Research output: Contribution to journalLetter

3 Scopus citations


In this response letter, technical issues raised by the comments concerning determination of arterial input function, cardiac and respiratory related motion artifacts, contrast agent application, and compartmental model fitting in our work are addressed in detail, and a discussion on identifying causes of uncertainty in physiological measurement and how to minimize their contribution is presented.

Original languageEnglish (US)
Article number5437346
Pages (from-to)1089-1092
Number of pages4
JournalIEEE Transactions on Medical Imaging
Issue number4
StatePublished - Apr 1 2010



  • Compartmental model
  • Dynamic contrast enhanced computed tomography (DCE-CT)
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Radiological and Ultrasound Technology
  • Software

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