Resting EEG in offspring of male alcoholics: Beta frequencies

Madhavi Rangaswamy, Bernice Porjesz, David B. Chorlian, Kongming Wang, Kevin A. Jones, Samuel Kuperman, John Rohrbaugh, Sean O'Connor, Lance O. Bauer, Theodore Reich, Henri Begleiter

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

This study examines the differences in beta (12-28 Hz) band power in offspring of male alcoholics from densely affected alcoholic families. We have attempted to investigate if the increase in beta power is a 'state' or 'trait' marker for alcoholism. This study also explores the gender differences in the expression of this potential risk marker. Absolute beta power in three bands - beta 1(12-16 Hz), beta 2 (16-20 Hz), and beta 3 (20-28 Hz) - in the eyes closed EEG of 171 high risk (HR) subjects who were offspring of male alcoholics and 204 low risk (LR) subjects with no family history of alcoholism, were compared for each gender separately using a repeated measures analysis of variance design. Alcoholic and non-alcoholic subjects within the high risk group were compared using a repeated measures design as a follow-up analysis. The present study demonstrated increased beta power in the resting EEG of offspring of male alcoholics. Male HR subjects had higher beta 1 (12-16 Hz) power and female HR subjects had increased power in beta 2 (16-20 Hz) and beta 3 (20-28 Hz) as compared with low risk participants. Female HR subjects also showed significantly increased beta 2 and beta 3 power if they had two or more alcoholic first-degree relatives when compared with HR females having only an affected father. Risk characteristics are expressed differentially in males and females and may be an index of differential vulnerability to alcoholism. The results indicate that increased EEG beta power can be considered as a likely marker of risk for developing alcoholism and may be used as a predictive endophenotype.

Original languageEnglish
Pages (from-to)239-251
Number of pages13
JournalInternational Journal of Psychophysiology
Volume51
Issue number3
DOIs
StatePublished - Feb 2004

Fingerprint

Alcoholics
Electroencephalography
Alcoholism
Endophenotypes
Power (Psychology)
Fathers
Analysis of Variance

Keywords

  • Absolute power
  • Alcoholism
  • Beta
  • EEG
  • Gender
  • High risk
  • Inhibition

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Wang, K., Jones, K. A., Kuperman, S., ... Begleiter, H. (2004). Resting EEG in offspring of male alcoholics: Beta frequencies. International Journal of Psychophysiology, 51(3), 239-251. https://doi.org/10.1016/j.ijpsycho.2003.09.003

Resting EEG in offspring of male alcoholics : Beta frequencies. / Rangaswamy, Madhavi; Porjesz, Bernice; Chorlian, David B.; Wang, Kongming; Jones, Kevin A.; Kuperman, Samuel; Rohrbaugh, John; O'Connor, Sean; Bauer, Lance O.; Reich, Theodore; Begleiter, Henri.

In: International Journal of Psychophysiology, Vol. 51, No. 3, 02.2004, p. 239-251.

Research output: Contribution to journalArticle

Rangaswamy, M, Porjesz, B, Chorlian, DB, Wang, K, Jones, KA, Kuperman, S, Rohrbaugh, J, O'Connor, S, Bauer, LO, Reich, T & Begleiter, H 2004, 'Resting EEG in offspring of male alcoholics: Beta frequencies', International Journal of Psychophysiology, vol. 51, no. 3, pp. 239-251. https://doi.org/10.1016/j.ijpsycho.2003.09.003
Rangaswamy M, Porjesz B, Chorlian DB, Wang K, Jones KA, Kuperman S et al. Resting EEG in offspring of male alcoholics: Beta frequencies. International Journal of Psychophysiology. 2004 Feb;51(3):239-251. https://doi.org/10.1016/j.ijpsycho.2003.09.003
Rangaswamy, Madhavi ; Porjesz, Bernice ; Chorlian, David B. ; Wang, Kongming ; Jones, Kevin A. ; Kuperman, Samuel ; Rohrbaugh, John ; O'Connor, Sean ; Bauer, Lance O. ; Reich, Theodore ; Begleiter, Henri. / Resting EEG in offspring of male alcoholics : Beta frequencies. In: International Journal of Psychophysiology. 2004 ; Vol. 51, No. 3. pp. 239-251.
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