Resting State Brain Network Disturbances Related to Hypomania and Depression in Medication-Free Bipolar Disorder

Jeffrey M. Spielberg, Erik B. Beall, Leslie Hulvershorn, Murat Altinay, Harish Karne, Amit Anand

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Research on resting functional brain networks in bipolar disorder (BP) has been unable to differentiate between disturbances related to mania or depression, which is necessary to understand the mechanisms leading to each state. Past research has also been unable to elucidate the impact of BP-related network disturbances on the organizational properties of the brain (eg, communication efficiency). Thus, the present work sought to isolate network disturbances related to BP, fractionate these into components associated with manic and depressive symptoms, and characterize the impact of disturbances on network function. Graph theory was used to analyze resting functional magnetic resonance imaging data from 60 medication-free patients meeting the criteria for BP and either a current hypomanic (n=30) or depressed (n=30) episode and 30 closely age/sex-matched healthy controls. Correction for multiple comparisons was carried out. Compared with controls, BP patients evidenced hyperconnectivity in a network involving right amygdala. Fractionation revealed that (hypo)manic symptoms were associated with hyperconnectivity in an overlapping network and disruptions in the brain’s ‘small-world’ network organization. Depressive symptoms predicted hyperconnectivity in a network involving orbitofrontal cortex along with a less resilient global network organization. Findings provide deeper insight into the differential pathophysiological processes associated with hypomania and depression, along with the particular impact these differential processes have on network function.Neuropsychopharmacology advance online publication, 20 July 2016; doi:10.1038/npp.2016.112.

Original languageEnglish (US)
JournalNeuropsychopharmacology
DOIs
StateAccepted/In press - Jul 20 2016

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Bipolar Disorder
Depression
Brain
Amygdala
Prefrontal Cortex
Research
Publications
Communication
Magnetic Resonance Imaging
Bipolar and Related Disorders

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Resting State Brain Network Disturbances Related to Hypomania and Depression in Medication-Free Bipolar Disorder. / Spielberg, Jeffrey M.; Beall, Erik B.; Hulvershorn, Leslie; Altinay, Murat; Karne, Harish; Anand, Amit.

In: Neuropsychopharmacology, 20.07.2016.

Research output: Contribution to journalArticle

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