Results and outcome of retroperitoneal lymph node dissection for clinical stage I embryonal carcinoma-predominant testis cancer

Christopher J. Sweeney, Benoit P. Hermans, Douglas K. Heilman, Richard S. Foster, John P. Donohue, Lawrence H. Einhorn

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Purpose: To determine the incidence of metastatic disease and usage of chemotherapy (adjuvant or metastatic) after primary retroperitoneal lymph node dissection (RPLND) in patients with clinical stage (CS) I embryonal carcinoma (EC)-predominant testicular cancer. EC predominance was defined as the presence of EC at a level greater than that of any other histologic diagnosis. Patients and Methods: All CS I patients with non-seminomatous germ cell tumors who underwent RPLND at Indiana University from 1990 to 1995 were reviewed retrospectively. Results: Two-year follow-up was available for 292 of 320 patients. EC-predominant disease was found in 125 (42.8%) of 292. Eighty-five (68.0%) of 125 patients with EC-predominant disease had pathologic stage (PS) I, and 18 (21.2%) of this group of 85 relapsed. A significantly lower PSI relapse rate of 3% was found for patients who had non-EC-predominant disease (P < .0001). PS II disease was more frequent in patients with EC predominance, as 40 (32.0%) of 125 had retroperitoneal metastases, compared with 26 (15.6%) of 167 patients with a non-EC- predominant histologic diagnosis (P = .0024). Chemotherapy was administered to 48 (38.4%) of the 125 patients with CS I EC-predominant disease after RPLND. This included 25 CS I patients with PS II disease who received adjuvant chemotherapy in addition to 23 patients who subsequently required chemotherapy for relapse after RPLND. Ten (66.6%) of 15 PS II EC-predominant patients were cured by surgery alone. Currently, all 125 EC-predominant patients are disease-free. Conclusion: Patients with CS I EC-predominant disease are at a relatively high risk for metastatic disease.

Original languageEnglish (US)
Pages (from-to)358-362
Number of pages5
JournalJournal of Clinical Oncology
Volume18
Issue number2
DOIs
StatePublished - Jan 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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