Results at a single centre of immunosuppression with cyclosporine A in 66 children with aplastic anaemia

Alexei Maschan, Natalia Bogatcheva, Oleg Kryjanovskii, Maria Shneider, Dimitry Litvinov, Tatiana Mitiushkina, Andrei Timakov, Maria Timakova, Elena Samotchatova, Alexander Rumiantsev

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A retrospective analysis of cyclosporine A (CsA) monotherapy administered to 66 children with aplastic anaemia (AA) at a single centre was carried out. The study was conducted on 66 children (F34/M32) with a median age of 10.5 years. 30 children (45%) achieved complete or partial remission within a median of 8 weeks. The response rate was 3/19 (16%) in cases of very severe aplastic anaemia (vSAA), 16/34 (47%) in severe aplastic anaemia (SAA) and 11/13 (85%) in nonSAA. 10 remitters (33%) relapsed after CsA cessation or dose tapering and six of those responded again on CsA alone. The only variable predictive for response was granulocyte count before treatment. The actuarial probability of survival was 51% at 4 years (85% in moderate AA, 50% in SAA and 32% in vSAA). The optimal dosage of CsA has yet to be established.

Original languageEnglish (US)
Pages (from-to)967-970
Number of pages4
JournalBritish journal of haematology
Volume106
Issue number4
DOIs
StatePublished - 1999

Keywords

  • Aplastic anaemia
  • Children
  • CsA trough level
  • Cyclosporine A
  • Immunosuppression

ASJC Scopus subject areas

  • Hematology

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    Maschan, A., Bogatcheva, N., Kryjanovskii, O., Shneider, M., Litvinov, D., Mitiushkina, T., Timakov, A., Timakova, M., Samotchatova, E., & Rumiantsev, A. (1999). Results at a single centre of immunosuppression with cyclosporine A in 66 children with aplastic anaemia. British journal of haematology, 106(4), 967-970. https://doi.org/10.1046/j.1365-2141.1999.01650.x