Retained fetal membranes in C57BL/6NCrl mice: Description of clinical case presentations and related epidemiologic findings

Jenelle K. Johnson, Tracy H. Vemulapalli, William G. Van Alstine, Christopher S. Roberts, Joseph P. Garner, Debra L. Hickman

Research output: Contribution to journalArticle

Abstract

During a triinstitutional study to test whether individually ventilated caging systems impaired welfare and reproduction relative to static housing systems, varying numbers (2 to 7) of discoid-shaped, fleshy structures were found in utero of 17 postpartum female mice on study. Further investigation revealed these structures to be retained fetal membranes (RFM). A point prevalence of 24.3% was calculated based on a total population of 70 postpartum female mice on study. This finding was preceded by 3 typical clinical presentations, which are described here. We designed a case-control matched cross-sectional epidemiologic study to identify associated risk factors and antemortem indicators of RFM. Housing on the bottom shelves and attachment to the rack systems were factors associated with a diagnosis of the condition. In addition, neutrophilia, monocytosis, lymphopenia, and decreasing hematocrit values were associated with the diagnosis of RFM. These results confirmed that a CBC can be a useful antemortem screening test for the identification of affected mice. We conclude that RFM are likely an incidental finding although they may present concurrent with other pregnancy complications.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalComparative medicine
Volume61
Issue number6
StatePublished - Dec 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Johnson, J. K., Vemulapalli, T. H., Van Alstine, W. G., Roberts, C. S., Garner, J. P., & Hickman, D. L. (2011). Retained fetal membranes in C57BL/6NCrl mice: Description of clinical case presentations and related epidemiologic findings. Comparative medicine, 61(6), 505-509.