Retinal blood flow during dynamic exercise

Alon Harris, Oliver Arend, Kathleen Bohnke, Elizabeth Kroepfl, Ronald Danis, Bruce Martin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

• Background: Exercise acutely lowers intraocular pressure (IOP) and raises arterial pressure. We wondered whether the resultant increase in ocular perfusion pressure would alter retinal blood flow. • Methods: To investigate this question, 11 healthy volunteers each performed progressive cycle ergometer exercise until exhaustion was reached in 5-10 min. Immediately after exercise, retinal blood flow and arteriovenous passage time were determined by video fluorescein angiography. Ten other volunteers performed repeated episodes of cycle ergometer exercise at approximately 60% of the maximal aerobic capacity, immediately prior to estimates of macular leukocyte velocity and density via blue-field stimulation. • Results: Progressive exercise lowered IOP and elevated calculated ocular perfusion pressure. Within the retinal circulation, this exercise tended to raise mean dye velocity, as it significantly narrowed the superior temporal artery and vein; as a result, calculated retinal blood flow was unchanged. Simultaneously, retinal arteriovenous passage time was substantially shortened. Blue-field simulation showed that exercise increased macular leukocyte velocity while leaving leukocyte density unchanged. • Conclusions: These results show that the normal retinal hemodynamic response to increases in perfusion pressure on dynamic exercise includes vasoconstriction that normalizes flow and faster capillary and overall retinal blood transit.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume234
Issue number7
DOIs
StatePublished - Jul 1996

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Exercise
Leukocytes
Perfusion
Intraocular Pressure
Pressure
Temporal Arteries
Fluorescein Angiography
Vasoconstriction
Volunteers
Veins
Healthy Volunteers
Arterial Pressure
Coloring Agents
Hemodynamics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinal blood flow during dynamic exercise. / Harris, Alon; Arend, Oliver; Bohnke, Kathleen; Kroepfl, Elizabeth; Danis, Ronald; Martin, Bruce.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 234, No. 7, 07.1996, p. 440-444.

Research output: Contribution to journalArticle

Harris, A, Arend, O, Bohnke, K, Kroepfl, E, Danis, R & Martin, B 1996, 'Retinal blood flow during dynamic exercise', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 234, no. 7, pp. 440-444. https://doi.org/10.1007/BF02539410
Harris, Alon ; Arend, Oliver ; Bohnke, Kathleen ; Kroepfl, Elizabeth ; Danis, Ronald ; Martin, Bruce. / Retinal blood flow during dynamic exercise. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 1996 ; Vol. 234, No. 7. pp. 440-444.
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