Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma

S. Wolf, O. Arend, W. E. Sponsel, K. Schulte, Louis Cantor, M. Reim

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Purpose: Recent studies suggest that elevated intraocular pressure is not the only causative factor for the development of visual field loss and optic nerve damage in glaucomatous eyes. The authors determine whether retinal hemodynamics or blood fluidity are alternated in eyes of patients with open- angle glaucoma compared with those of age- and sex-matched healthy subjects. Method: High-quality video fluorescein angiograms were obtained from single eyes of 51 patients with chronic open-angle glaucoma. From these angiograms, the arm-retina time, mean dye velocity, and arteriovenous passage time were quantified. The data from patients were compared with those of an age- and sex-matched group of healthy subjects. Results: In patients with chronic open-angle glaucoma, an 11% reduction of the mean dye velocity (P <0.05) and a 41% prolongation of the arteriovenous passage time (P <0.01) was observed relative to the values obtained among the control subjects. Among hematocrit values, plasma viscosity, and erythrocyte aggregation, only plasma viscosity showed a significant increase (4%; P <0.01) in patients with chronic open- angle glaucoma. Conclusion: These results indicate that a pronounced circulatory deficit exists within the retinal vasculature of glaucomatous eyes, which may coexist with, but cannot be fully attributed to, an increase in plasma viscosity.

Original languageEnglish (US)
Pages (from-to)1561-1566
Number of pages6
JournalOphthalmology
Volume100
Issue number10
StatePublished - 1993

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Hemorheology
Ophthalmoscopy
Open Angle Glaucoma
Lasers
Hemodynamics
Viscosity
Healthy Volunteers
Angiography
Coloring Agents
Erythrocyte Aggregation
Optic Nerve
Visual Fields
Fluorescein
Intraocular Pressure
Hematocrit
Retina
Arm
Research Design

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wolf, S., Arend, O., Sponsel, W. E., Schulte, K., Cantor, L., & Reim, M. (1993). Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma. Ophthalmology, 100(10), 1561-1566.

Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma. / Wolf, S.; Arend, O.; Sponsel, W. E.; Schulte, K.; Cantor, Louis; Reim, M.

In: Ophthalmology, Vol. 100, No. 10, 1993, p. 1561-1566.

Research output: Contribution to journalArticle

Wolf, S, Arend, O, Sponsel, WE, Schulte, K, Cantor, L & Reim, M 1993, 'Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma', Ophthalmology, vol. 100, no. 10, pp. 1561-1566.
Wolf, S. ; Arend, O. ; Sponsel, W. E. ; Schulte, K. ; Cantor, Louis ; Reim, M. / Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma. In: Ophthalmology. 1993 ; Vol. 100, No. 10. pp. 1561-1566.
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