Retinal photodamage

Mike Boulton, Malgorzata Rózanowska, Bartosz Rózanowski

Research output: Contribution to journalArticlepeer-review

256 Scopus citations

Abstract

The retina represents a paradox, in that, while light and oxygen are essential for vision, these conditions also favour the formation of reactive oxygen species leading to photochemical damage to the retina. Such light damage seems to be multi-factorial and is dependent on the photoreactivity of a variety of chromophores (e.g., vitamin A metabolites, lipofuscin, melanin, flavins, porphyrins, carotenoids) endogenous to the retina. The aim of this article is to provide a detailed review of our current understanding of the photochemistry and photobiology of these chromophores and to consider how they may contribute to retinal ageing and pathology.

Original languageEnglish (US)
Pages (from-to)144-161
Number of pages18
JournalJournal of Photochemistry and Photobiology B: Biology
Volume64
Issue number2-3
DOIs
StatePublished - Nov 15 2001

Keywords

  • Light damage
  • Lipofuscin
  • Macular pigment
  • Melanin
  • Retina
  • Retinal

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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