Retinal pigment epithelial dystrophy in Briard dogs

R. M. Lightfoot, L. Cabral, L. Gooch, P. G C Bedford, M. E. Boulton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The eyes of normal Briard dogs, Briards affected with inherited retinal pigment epithelial dystrophy (RPED) and a range of normal crossbred and beagle dogs were examined and the histopathology of RPED in the Briard was compared with the histopathological features of ageing in the normal canine retina. RPED was characterised by the accumulation of auto-fluorescent lipofuscin-like inclusions in the retinal pigment epithelium (RPE), which initially involved only non-pigmented RPE cells overlying the tapetum but subsequently spread to all pigmented RPE cells. Secondary neuro-retinal degeneration was characterised by a gradual loss of the outer nuclear layer and the subsequent atrophy and degeneration of the inner retina. The loss of primary photoreceptors in the peripheral retina was accompanied by the migration of photoreceptor nuclei and appeared to resemble severe changes due to ageing. Intra-vitreal radiolabelled leucine was used to examine the rate of turnover of the outer segments of the rods in some Briards, but no significant variations were found. The activity of acid phosphatase in RPE was assayed in vitro and showed comparable regional variations in Briard and crossbred dogs. The results suggest that RPED in the Briard is unlikely to be due either to an increased rate of turnover of rod outer segments (and thus an increased phagocytic load) or to a primary insufficiency of lysosomal enzyme.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalResearch in Veterinary Science
Volume60
Issue number1
StatePublished - Jan 1996
Externally publishedYes

Fingerprint

Retinal Pigments
Retinal Pigment Epithelium
pigments
Dogs
Rod Cell Outer Segment
Retina
dogs
epithelium
retina
rods (retina)
Lipofuscin
Retinal Degeneration
Acid Phosphatase
photoreceptors
Leucine
Atrophy
Canidae
crossbreds
Reference Values
Enzymes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Lightfoot, R. M., Cabral, L., Gooch, L., Bedford, P. G. C., & Boulton, M. E. (1996). Retinal pigment epithelial dystrophy in Briard dogs. Research in Veterinary Science, 60(1), 17-23.

Retinal pigment epithelial dystrophy in Briard dogs. / Lightfoot, R. M.; Cabral, L.; Gooch, L.; Bedford, P. G C; Boulton, M. E.

In: Research in Veterinary Science, Vol. 60, No. 1, 01.1996, p. 17-23.

Research output: Contribution to journalArticle

Lightfoot, RM, Cabral, L, Gooch, L, Bedford, PGC & Boulton, ME 1996, 'Retinal pigment epithelial dystrophy in Briard dogs', Research in Veterinary Science, vol. 60, no. 1, pp. 17-23.
Lightfoot RM, Cabral L, Gooch L, Bedford PGC, Boulton ME. Retinal pigment epithelial dystrophy in Briard dogs. Research in Veterinary Science. 1996 Jan;60(1):17-23.
Lightfoot, R. M. ; Cabral, L. ; Gooch, L. ; Bedford, P. G C ; Boulton, M. E. / Retinal pigment epithelial dystrophy in Briard dogs. In: Research in Veterinary Science. 1996 ; Vol. 60, No. 1. pp. 17-23.
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