Retinal S-antigen immunoreactivity in medulloblastomas

J. M. Bonnin, E. Perentes

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.

Original languageEnglish (US)
Pages (from-to)204-207
Number of pages4
JournalActa Neuropathologica
Volume76
Issue number2
DOIs
StatePublished - Mar 1 1988
Externally publishedYes

Keywords

  • Cerebellar medulloblastoma
  • Monoclonal antibodies
  • Photoreceptor cells
  • S-Antigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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