Retinal S-antigen immunoreactivity in medulloblastomas

Jose Bonnin, E. Perentes

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.

Original languageEnglish (US)
Pages (from-to)204-207
Number of pages4
JournalActa Neuropathologica
Volume76
Issue number2
DOIs
StatePublished - Mar 1988
Externally publishedYes

Fingerprint

Pinealoma
Arrestin
Medulloblastoma
Photoreceptor Cells
Vertebrate Photoreceptor Cells
Pineal Gland
Retinoblastoma
Cell Lineage
Epitopes
Cell Count
Monoclonal Antibodies
Antigens
Neoplasms
Proteins

Keywords

  • Cerebellar medulloblastoma
  • Monoclonal antibodies
  • Photoreceptor cells
  • S-Antigen

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Retinal S-antigen immunoreactivity in medulloblastomas. / Bonnin, Jose; Perentes, E.

In: Acta Neuropathologica, Vol. 76, No. 2, 03.1988, p. 204-207.

Research output: Contribution to journalArticle

Bonnin, Jose ; Perentes, E. / Retinal S-antigen immunoreactivity in medulloblastomas. In: Acta Neuropathologica. 1988 ; Vol. 76, No. 2. pp. 204-207.
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