Retinoblastoma, the visible CNS tumor: A review

Helen Dimaras, Timothy Corson

Research output: Contribution to journalReview article

Abstract

The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor readily observed without specialized equipment: it can be seen by, and in, the naked eye. This accessibility enables unique imaging modalities. Here, we review this cancer for a neuroscience audience, highlighting these clinical and research imaging options, including fundus imaging, optical coherence tomography, ultrasound, and magnetic resonance imaging. We also discuss the subtype of retinoblastoma driven by the MYCN oncogene more commonly associated with neuroblastoma, and consider trilateral retinoblastoma, in which an intracranial tumor arises along with ocular tumors in patients with germline RB1 gene mutations. Retinoblastoma research and clinical care can offer insights applicable to CNS malignancies, and also benefit from approaches developed elsewhere in the CNS.

LanguageEnglish (US)
Pages29-44
Number of pages16
JournalJournal of Neuroscience Research
Volume97
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Central Nervous System Neoplasms
Retinoblastoma
Neoplasms
Eye Neoplasms
Central Nervous System
Optical Coherence Tomography
Neurosciences
Neuroblastoma
Oncogenes
Research
Magnetic Resonance Imaging
Pediatrics
Equipment and Supplies
Mutation
Genes

Keywords

  • cancer genetics
  • MYCN
  • neuroimaging
  • optical coherence tomography
  • pediatric cancer
  • pineoblastoma

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Retinoblastoma, the visible CNS tumor : A review. / Dimaras, Helen; Corson, Timothy.

In: Journal of Neuroscience Research, Vol. 97, No. 1, 01.01.2019, p. 29-44.

Research output: Contribution to journalReview article

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