Retinoic acid signal transduction pathways

M. Leid, P. Kastner, B. Durand, A. Krust, P. Leroy, R. Lyons, C. Mendelsohn, S. Nagpal, Harikrishna Nakshatri, C. Reibel, M. Saunders, P. Chambon

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Complexity in the retinoid signaling system arises from a combination of several forms of retinoic acid which possess differential activities, multiple cytoplasmic binding proteins and nuclear receptors that have distinct ligand specificities and functional properties, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between the two classes of nuclear retinoic acid receptors and between retinoic acid receptors and some other members of the nuclear receptor superfamily. Thus, a complex array of combinatorial effects is beginning to emerge that may account for the pleiotropic effects of retinoids.

Original languageEnglish (US)
Pages (from-to)19-34
Number of pages16
JournalAnnals of the New York Academy of Sciences
Volume684
StatePublished - 1993
Externally publishedYes

Fingerprint

Signal transduction
Retinoic Acid Receptors
Retinoids
Cytoplasmic and Nuclear Receptors
Tretinoin
Signal Transduction
Response Elements
Carrier Proteins
Ligands
Transduction
Pathway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Leid, M., Kastner, P., Durand, B., Krust, A., Leroy, P., Lyons, R., ... Chambon, P. (1993). Retinoic acid signal transduction pathways. Annals of the New York Academy of Sciences, 684, 19-34.

Retinoic acid signal transduction pathways. / Leid, M.; Kastner, P.; Durand, B.; Krust, A.; Leroy, P.; Lyons, R.; Mendelsohn, C.; Nagpal, S.; Nakshatri, Harikrishna; Reibel, C.; Saunders, M.; Chambon, P.

In: Annals of the New York Academy of Sciences, Vol. 684, 1993, p. 19-34.

Research output: Contribution to journalArticle

Leid, M, Kastner, P, Durand, B, Krust, A, Leroy, P, Lyons, R, Mendelsohn, C, Nagpal, S, Nakshatri, H, Reibel, C, Saunders, M & Chambon, P 1993, 'Retinoic acid signal transduction pathways', Annals of the New York Academy of Sciences, vol. 684, pp. 19-34.
Leid M, Kastner P, Durand B, Krust A, Leroy P, Lyons R et al. Retinoic acid signal transduction pathways. Annals of the New York Academy of Sciences. 1993;684:19-34.
Leid, M. ; Kastner, P. ; Durand, B. ; Krust, A. ; Leroy, P. ; Lyons, R. ; Mendelsohn, C. ; Nagpal, S. ; Nakshatri, Harikrishna ; Reibel, C. ; Saunders, M. ; Chambon, P. / Retinoic acid signal transduction pathways. In: Annals of the New York Academy of Sciences. 1993 ; Vol. 684. pp. 19-34.
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AU - Mendelsohn, C.

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