Retinoid receptors and binding proteins

David Lohnes, Andrée Dierich, Norbert Ghyselinck, Phillipe Kastner, Carmen Lampron, Marianne LeMeur, Thomas Lufkin, Cathy Mendelsohn, Harikrishna Nakshatri, Pierre Chambon

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Retinoids, in particular all-trans retinoic acid (T-RA), are essential for normal development and homeostasis of vertebrates. Although many effects of retinoids, particularity with regard to teratogenicity, have been described in the literature, the mechanisms by which these simple signalling molecules work has only recently begun to be elucidated. We now recognize at least two classes of retinoid-binding proteins and two families of retinoid receptors. The ultimate interpretation of the retinoid signal within a given cell is probably the result of a complex series of interactions between these proteins, yet little is understood concerning the role each member of this signalling pathway plays. It is therefore imperative to dissect the molecular mechanisms which transduce the effects of these ligands, both in vivo and in isolated systems. One approach we are employing is gene targeting of retinoic acid receptors (RARs) and cellular retinoid-binding proteins to generate mice in which one or more of these genes has been functionally inactivated.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalJournal of Cell Science
Volume102
Issue numberSUPPL. 16
StatePublished - 1992
Externally publishedYes

Fingerprint

Retinol-Binding Proteins
Retinoids
Retinoic Acid Receptors
Gene Targeting
Tretinoin
Vertebrates
Homeostasis
Ligands
Genes
Proteins

Keywords

  • Cellular retinoic acid-binding protein
  • Cellular retinol-binding protein
  • Gene targeting
  • Retinoic acid receptors
  • Retinoid X receptors

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Lohnes, D., Dierich, A., Ghyselinck, N., Kastner, P., Lampron, C., LeMeur, M., ... Chambon, P. (1992). Retinoid receptors and binding proteins. Journal of Cell Science, 102(SUPPL. 16), 69-76.

Retinoid receptors and binding proteins. / Lohnes, David; Dierich, Andrée; Ghyselinck, Norbert; Kastner, Phillipe; Lampron, Carmen; LeMeur, Marianne; Lufkin, Thomas; Mendelsohn, Cathy; Nakshatri, Harikrishna; Chambon, Pierre.

In: Journal of Cell Science, Vol. 102, No. SUPPL. 16, 1992, p. 69-76.

Research output: Contribution to journalArticle

Lohnes, D, Dierich, A, Ghyselinck, N, Kastner, P, Lampron, C, LeMeur, M, Lufkin, T, Mendelsohn, C, Nakshatri, H & Chambon, P 1992, 'Retinoid receptors and binding proteins', Journal of Cell Science, vol. 102, no. SUPPL. 16, pp. 69-76.
Lohnes D, Dierich A, Ghyselinck N, Kastner P, Lampron C, LeMeur M et al. Retinoid receptors and binding proteins. Journal of Cell Science. 1992;102(SUPPL. 16):69-76.
Lohnes, David ; Dierich, Andrée ; Ghyselinck, Norbert ; Kastner, Phillipe ; Lampron, Carmen ; LeMeur, Marianne ; Lufkin, Thomas ; Mendelsohn, Cathy ; Nakshatri, Harikrishna ; Chambon, Pierre. / Retinoid receptors and binding proteins. In: Journal of Cell Science. 1992 ; Vol. 102, No. SUPPL. 16. pp. 69-76.
@article{486a9f502be74dbcb1b84d6cc2f1eea6,
title = "Retinoid receptors and binding proteins",
abstract = "Retinoids, in particular all-trans retinoic acid (T-RA), are essential for normal development and homeostasis of vertebrates. Although many effects of retinoids, particularity with regard to teratogenicity, have been described in the literature, the mechanisms by which these simple signalling molecules work has only recently begun to be elucidated. We now recognize at least two classes of retinoid-binding proteins and two families of retinoid receptors. The ultimate interpretation of the retinoid signal within a given cell is probably the result of a complex series of interactions between these proteins, yet little is understood concerning the role each member of this signalling pathway plays. It is therefore imperative to dissect the molecular mechanisms which transduce the effects of these ligands, both in vivo and in isolated systems. One approach we are employing is gene targeting of retinoic acid receptors (RARs) and cellular retinoid-binding proteins to generate mice in which one or more of these genes has been functionally inactivated.",
keywords = "Cellular retinoic acid-binding protein, Cellular retinol-binding protein, Gene targeting, Retinoic acid receptors, Retinoid X receptors",
author = "David Lohnes and Andr{\'e}e Dierich and Norbert Ghyselinck and Phillipe Kastner and Carmen Lampron and Marianne LeMeur and Thomas Lufkin and Cathy Mendelsohn and Harikrishna Nakshatri and Pierre Chambon",
year = "1992",
language = "English (US)",
volume = "102",
pages = "69--76",
journal = "Journal of Cell Science",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "SUPPL. 16",

}

TY - JOUR

T1 - Retinoid receptors and binding proteins

AU - Lohnes, David

AU - Dierich, Andrée

AU - Ghyselinck, Norbert

AU - Kastner, Phillipe

AU - Lampron, Carmen

AU - LeMeur, Marianne

AU - Lufkin, Thomas

AU - Mendelsohn, Cathy

AU - Nakshatri, Harikrishna

AU - Chambon, Pierre

PY - 1992

Y1 - 1992

N2 - Retinoids, in particular all-trans retinoic acid (T-RA), are essential for normal development and homeostasis of vertebrates. Although many effects of retinoids, particularity with regard to teratogenicity, have been described in the literature, the mechanisms by which these simple signalling molecules work has only recently begun to be elucidated. We now recognize at least two classes of retinoid-binding proteins and two families of retinoid receptors. The ultimate interpretation of the retinoid signal within a given cell is probably the result of a complex series of interactions between these proteins, yet little is understood concerning the role each member of this signalling pathway plays. It is therefore imperative to dissect the molecular mechanisms which transduce the effects of these ligands, both in vivo and in isolated systems. One approach we are employing is gene targeting of retinoic acid receptors (RARs) and cellular retinoid-binding proteins to generate mice in which one or more of these genes has been functionally inactivated.

AB - Retinoids, in particular all-trans retinoic acid (T-RA), are essential for normal development and homeostasis of vertebrates. Although many effects of retinoids, particularity with regard to teratogenicity, have been described in the literature, the mechanisms by which these simple signalling molecules work has only recently begun to be elucidated. We now recognize at least two classes of retinoid-binding proteins and two families of retinoid receptors. The ultimate interpretation of the retinoid signal within a given cell is probably the result of a complex series of interactions between these proteins, yet little is understood concerning the role each member of this signalling pathway plays. It is therefore imperative to dissect the molecular mechanisms which transduce the effects of these ligands, both in vivo and in isolated systems. One approach we are employing is gene targeting of retinoic acid receptors (RARs) and cellular retinoid-binding proteins to generate mice in which one or more of these genes has been functionally inactivated.

KW - Cellular retinoic acid-binding protein

KW - Cellular retinol-binding protein

KW - Gene targeting

KW - Retinoic acid receptors

KW - Retinoid X receptors

UR - http://www.scopus.com/inward/record.url?scp=0027021836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027021836&partnerID=8YFLogxK

M3 - Article

VL - 102

SP - 69

EP - 76

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

IS - SUPPL. 16

ER -