Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma

Alon Harris, G. L. Spaeth, R. C. Sergott, L. J. Katz, Louis Cantor, B. J. Martin

Research output: Contribution to journalArticle

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Abstract

PURPOSE: β-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS: We compared the effect of selective (betaxolol) and nonselective (timolol) β-adrenergic blocking drugs on flow velocities (as determined by color Doppler imaging) in orbital vessels in 13 patients with normal-tension glaucoma (mean age, 62 ± 3 years; mean intraocular pressure, 15 ± 2 mm Hg). A one-month drug treatment double-masked crossover design, with a three-week washout before each drug, was used. RESULTS: Neither drug changed peak systolic velocity in any of the four vessels studied (ophthalmic, nasal and temporal posterior ciliary, and central retinal arteries). Additionally, timolol did not alter end-diastolic velocity or resistance index (defined as [peak systolic velocity minus end-diastolic velocity] divided by peak systolic velocity) in any of the vessels measured. In contrast, betaxolol tended to increase end-diastolic velocity and to decrease resistance index: the four-vessel average end-diastolic velocity increased 30% (P = .08), and the four-vessel average resistance index decreased significantly (P = .04). These reductions in resistance index occurred despite that betaxolol, in contrast to timolol, did not significantly decrease intraocular pressure. CONCLUSIONS: These results suggest that, in patients with normal-tension glaucoma, selective β-adrenergic blockade (betaxolol) may have ocular vasorelaxant effects independent of any influence on intraocular pressure, whereas nonselective blockade (timolol) lowers intraocular pressure without apparently altering orbital hemodynamics.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume120
Issue number2
StatePublished - 1995

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Betaxolol
Low Tension Glaucoma
Timolol
Intraocular Pressure
Hemodynamics
Adrenergic Agents
Pharmaceutical Preparations
Retinal Artery
Vasodilator Agents
Nose
Cross-Over Studies
Color

ASJC Scopus subject areas

  • Ophthalmology

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Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. / Harris, Alon; Spaeth, G. L.; Sergott, R. C.; Katz, L. J.; Cantor, Louis; Martin, B. J.

In: American Journal of Ophthalmology, Vol. 120, No. 2, 1995, p. 168-175.

Research output: Contribution to journalArticle

Harris, Alon ; Spaeth, G. L. ; Sergott, R. C. ; Katz, L. J. ; Cantor, Louis ; Martin, B. J. / Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. In: American Journal of Ophthalmology. 1995 ; Vol. 120, No. 2. pp. 168-175.
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AU - Cantor, Louis

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