Retroperitoneal and truncal sarcomas

Prognosis depends upon type not location

Eduardo A. Perez, Juan C. Gutierrez, Frederick L. Moffat, Dido Franceschi, Alan S. Livingstone, Seth A. Spector, Joe U. Levi, Danny Sleeman, Leonidas Koniaris

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: Prognostication of truncal and retroperitoneal soft tissue sarcomas has traditionally been predicated on tumor location and grade. Objective: To compare outcomes for patients with retroperitoneal or truncal sarcomas. Methods: Retrospective analysis of a prospective cancer data registry from 1977 to 2004 was performed and outcomes were determined. Results: The study group numbered 312 patients (median age 58 years, 54% male, 56% Caucasian, 14% black, 29% Hispanic). The most common tumor types were liposarcoma (35.9%), leiomyosarcoma (30.1%), and malignant fibrous histiocytoma (MFH) (19.5%). Tumor distributions were retroperitoneal (38.9%), pelvic (24.7%), abdominal (18.6%) and thoracic (17.9%). Median overall survival was 74 months. Operative resection was undertaken in 89.4% of cases and multiple surgeries (range 2-5) in 42.2%. Negative resection margins were obtained in 72.7% of patients. Univariate analysis comparing retroperitoneal versus truncal location demonstrated no significant differences in survival. Survival was improved in lower grade tumors (P <0.02). Liposarcoma and fibrosarcoma were associated with improved survival (P <0.0001). Multivariate analysis of pre-treatment variables showed increasing age, grade, histopathology (leiomyosarcoma and MFH) and metastasis to be associated with worse outcomes. Multivariate analysis of the treatment variables showed that surgery and negative resection margins were associated with improved survival (P <0.001). No advantage for chemoradiotherapy could be demonstrated. Conclusions: Successful operative resection can confer prolonged disease-free survival and cure for truncal and retroperitoneal sarcomas. Histological subtype, not location, is predictive of long-term survival. Future studies should focus on histological subtype rather than tumor location for truncal and retroperitoneal sarcomas. Published by Springer Science+Business Media, Inc.

Original languageEnglish (US)
Pages (from-to)1114-1122
Number of pages9
JournalAnnals of Surgical Oncology
Volume14
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Sarcoma
Survival
Malignant Fibrous Histiocytoma
Liposarcoma
Neoplasms
Leiomyosarcoma
Multivariate Analysis
Fibrosarcoma
Chemoradiotherapy
Hispanic Americans
Disease-Free Survival
Registries
Thorax
Neoplasm Metastasis
Therapeutics
Margins of Excision

Keywords

  • Chemotheraphy
  • Outcomes
  • Radiation
  • Review
  • Sarcoma
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Perez, E. A., Gutierrez, J. C., Moffat, F. L., Franceschi, D., Livingstone, A. S., Spector, S. A., ... Koniaris, L. (2007). Retroperitoneal and truncal sarcomas: Prognosis depends upon type not location. Annals of Surgical Oncology, 14(3), 1114-1122. https://doi.org/10.1245/s10434-006-9255-x

Retroperitoneal and truncal sarcomas : Prognosis depends upon type not location. / Perez, Eduardo A.; Gutierrez, Juan C.; Moffat, Frederick L.; Franceschi, Dido; Livingstone, Alan S.; Spector, Seth A.; Levi, Joe U.; Sleeman, Danny; Koniaris, Leonidas.

In: Annals of Surgical Oncology, Vol. 14, No. 3, 03.2007, p. 1114-1122.

Research output: Contribution to journalArticle

Perez, EA, Gutierrez, JC, Moffat, FL, Franceschi, D, Livingstone, AS, Spector, SA, Levi, JU, Sleeman, D & Koniaris, L 2007, 'Retroperitoneal and truncal sarcomas: Prognosis depends upon type not location', Annals of Surgical Oncology, vol. 14, no. 3, pp. 1114-1122. https://doi.org/10.1245/s10434-006-9255-x
Perez EA, Gutierrez JC, Moffat FL, Franceschi D, Livingstone AS, Spector SA et al. Retroperitoneal and truncal sarcomas: Prognosis depends upon type not location. Annals of Surgical Oncology. 2007 Mar;14(3):1114-1122. https://doi.org/10.1245/s10434-006-9255-x
Perez, Eduardo A. ; Gutierrez, Juan C. ; Moffat, Frederick L. ; Franceschi, Dido ; Livingstone, Alan S. ; Spector, Seth A. ; Levi, Joe U. ; Sleeman, Danny ; Koniaris, Leonidas. / Retroperitoneal and truncal sarcomas : Prognosis depends upon type not location. In: Annals of Surgical Oncology. 2007 ; Vol. 14, No. 3. pp. 1114-1122.
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AU - Gutierrez, Juan C.

AU - Moffat, Frederick L.

AU - Franceschi, Dido

AU - Livingstone, Alan S.

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