Retrospective analysis of risk factors in patients with treatment-emergent diabetes during clinical trials of antipsychotic medications

Patrizia Cavazzoni, Nitai Mukhopadhyay, Christopher Carlson, Alan Breier, John Buse

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aims: In this retrospective analysis, we assessed the short-term risk of treatment-emergent diabetes (TED) among patients with schizophrenia during clinical trials of antipsychotic medications. Method: From a non-diabetic cohort of patients with schizophrenia (n=5013), the relationship between baseline non-fasting glucose measurement, presence at baseline of risk factors for diabetes, weight gain and therapy assignment on the risk of treatment-emergent diabetes were assessed. Results: At the baseline assessment, about a third of patients identified with TED during treatment had non-fasting glucose levels over 7.8 mmol/l and two-thirds had multiple diabetes risk factors. Both baseline non-fasting glucose level and the presence of multiple pre-existing diabetes risk factors appeared to have a major impact on the risk of developing diabetes. Conclusions: Overall, risk factors for diabetes in patients with schizophrenia overlap those in the general population. The results also suggest that many patients identified withTED might have had pre-existing glycaemic abnormalities or a high baseline burden of diabetes risk factors.

Original languageEnglish (US)
JournalBritish Journal of Psychiatry
Volume184
Issue numberSUPPL. 47
DOIs
StatePublished - Apr 2004

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Antipsychotic Agents
Clinical Trials
Schizophrenia
Glucose
Therapeutics
Weight Gain
Population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

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Retrospective analysis of risk factors in patients with treatment-emergent diabetes during clinical trials of antipsychotic medications. / Cavazzoni, Patrizia; Mukhopadhyay, Nitai; Carlson, Christopher; Breier, Alan; Buse, John.

In: British Journal of Psychiatry, Vol. 184, No. SUPPL. 47, 04.2004.

Research output: Contribution to journalArticle

Cavazzoni, Patrizia ; Mukhopadhyay, Nitai ; Carlson, Christopher ; Breier, Alan ; Buse, John. / Retrospective analysis of risk factors in patients with treatment-emergent diabetes during clinical trials of antipsychotic medications. In: British Journal of Psychiatry. 2004 ; Vol. 184, No. SUPPL. 47.
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