Reversibility of prostatic intraepithelial neoplasia: Implications for chemoprevention

D. G. Bostwick, R. Neumann, J. Qian, L. Cheng

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

High-grade prostatic intraepithelial neoplasia is the most likely precursor of prostatic adenocarcinoma, according to virtually all available evidence. It has a high predictive value as a marker for adenocarcinoma, and its identification in biopsy specimens of the prostate warrants further search for concurrent invasive carcinoma. Androgen deprivation therapy and radiation therapy decrease its prevalence and extent, suggesting a role in chemoprevention.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalEuropean urology
Volume35
Issue number5-6
DOIs
StatePublished - May 26 1999
Externally publishedYes

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Keywords

  • Androgen deprivation therapy
  • Chemoprevention
  • Hormonal therapy
  • Prostate neoplasms
  • Prostatic carcinoma
  • Prostatic intraepithelial neoplasia
  • Radiation therapy

ASJC Scopus subject areas

  • Urology

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