Reversible inhibition of electron transfer in the ubiquinol. Cytochrome c reductase segment of the mitochondrial respiratory chain in hibernating ground squirrels

Nikolai Broustovetski, Z. G. Amerkhanov, E. Yu Popova, A. A. Konstantinov

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Electron transfer through the ubiquinol:cytochrome c1-segment of liver mitochondria isolated from hibernating ground squirrels Citellus undulatus is repressed by 70-80% as compared to mitochondria from the active animals. The inhibition site is likely to be localized between ubiquinone and the cytochrome bc1, complex. Partial release of the inhibition can be observed upon swelling of the isolated mitochondria in a hypoosmotie medium, the effect being prevented by phospholipase A2 inhibitors. Possible role of phospholipase A2 in regulation of ubiquinol oxidation by complex bc1, is discussed.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalFEBS Letters
Volume263
Issue number1
DOIs
StatePublished - Apr 9 1990
Externally publishedYes

Fingerprint

Cytochrome Reductases
Sciuridae
Mitochondria
Electron Transport
Cytochromes c
Oxidoreductases
Phospholipase A2 Inhibitors
Electrons
Cytochromes c1
Ubiquinone
Liver Mitochondrion
Electron Transport Complex III
Phospholipases A2
Liver
Swelling
Animals
Oxidation
ubiquinol

Keywords

  • Citellus undulatus
  • Electron flow regulation
  • Hibernation
  • Oxidative phosphorylation
  • Phospholipase A
  • Ubiquinol: cytochrome c reductase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Reversible inhibition of electron transfer in the ubiquinol. Cytochrome c reductase segment of the mitochondrial respiratory chain in hibernating ground squirrels. / Broustovetski, Nikolai; Amerkhanov, Z. G.; Popova, E. Yu; Konstantinov, A. A.

In: FEBS Letters, Vol. 263, No. 1, 09.04.1990, p. 73-76.

Research output: Contribution to journalArticle

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