Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers

Paul C. Edwards, John E. Fantasia

Research output: Contribution to journalReview article

35 Scopus citations


Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as “redefining” dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.

Original languageEnglish (US)
Pages (from-to)509-519
Number of pages11
JournalClinical interventions in aging
Issue number4
StatePublished - Jan 1 2007



  • Foreign body reaction
  • Granuloma
  • Hyaluronic acid
  • Hylaform®
  • Injectable dermal filler
  • Restylane®

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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