Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium

Tamara Hannon, Steven E. Kahn, Kristina M. Utzschneider, Thomas A. Buchanan, Kristen J. Nadeau, Philip S. Zeitler, David A. Ehrmann, Silva A. Arslanian, Sonia Caprio, Sharon L. Edelstein, Peter J. Savage, Kieren Mather

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Restoring Insulin Secretion (RISE) study was initiated to evaluate interventions to slow or reverse the progression of β-cell failure in type 2 diabetes (T2D). To design the RISE study, we undertook an evaluation of methods for measurement of β-cell function and changes in β-cell function in response to interventions. In the present paper, we review approaches for measurement of β-cell function, focusing on methodologic and feasibility considerations. Methodologic considerations included: (1) the utility of each technique for evaluating key aspects of β-cell function (first- and second-phase insulin secretion, maximum insulin secretion, glucose sensitivity, incretin effects) and (2) tactics for incorporating a measurement of insulin sensitivity in order to adjust insulin secretion measures for insulin sensitivity appropriately. Of particular concern were the capacity to measure β-cell function accurately in those with poor function, as is seen in established T2D, and the capacity of each method for demonstrating treatment-induced changes in β-cell function. Feasibility considerations included: staff burden, including time and required methodological expertise; participant burden, including time and number of study visits; and ease of standardizing methods across a multicentre consortium. After this evaluation, we selected a 2-day measurement procedure, combining a 3-hour 75-g oral glucose tolerance test and a 2-stage hyperglycaemic clamp procedure, augmented with arginine.

Original languageEnglish (US)
JournalDiabetes, Obesity and Metabolism
DOIs
StateAccepted/In press - 2017

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Insulin
Type 2 Diabetes Mellitus
Insulin Resistance
Incretins
Glucose Tolerance Test
Arginine
Glucose

Keywords

  • Glucose metabolism
  • Insulin resistance
  • Insulin secretion
  • Type 2 diabetes
  • β cell

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Review of methods for measuring β-cell function : Design considerations from the Restoring Insulin Secretion (RISE) Consortium. / Hannon, Tamara; Kahn, Steven E.; Utzschneider, Kristina M.; Buchanan, Thomas A.; Nadeau, Kristen J.; Zeitler, Philip S.; Ehrmann, David A.; Arslanian, Silva A.; Caprio, Sonia; Edelstein, Sharon L.; Savage, Peter J.; Mather, Kieren.

In: Diabetes, Obesity and Metabolism, 2017.

Research output: Contribution to journalArticle

Hannon, T, Kahn, SE, Utzschneider, KM, Buchanan, TA, Nadeau, KJ, Zeitler, PS, Ehrmann, DA, Arslanian, SA, Caprio, S, Edelstein, SL, Savage, PJ & Mather, K 2017, 'Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium', Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.13005
Hannon, Tamara ; Kahn, Steven E. ; Utzschneider, Kristina M. ; Buchanan, Thomas A. ; Nadeau, Kristen J. ; Zeitler, Philip S. ; Ehrmann, David A. ; Arslanian, Silva A. ; Caprio, Sonia ; Edelstein, Sharon L. ; Savage, Peter J. ; Mather, Kieren. / Review of methods for measuring β-cell function : Design considerations from the Restoring Insulin Secretion (RISE) Consortium. In: Diabetes, Obesity and Metabolism. 2017.
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