Review of nonprimate, large animal models for osteoporosis research

Susan Reinwald, David Burr

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Large animal models are required for preclinical prevention and intervention studies related to osteoporosis research. The challenging aspect of this requirement is that no single animal model exactly mimics the progression of this human-specific chronic condition. There are pros and cons associated with the skeletal, hormonal, and metabolic conditions of each species that influence their relevance and applicability to human physiology. Of all larger mammalian species, nonhuman primates (NHPs) are preeminent in terms of replicating important aspects of human physiology. However, NHPs are very expensive, putting them out of reach of the vast majority of researchers. Practical, cost-effective alternatives to NHPs are sought after among ungulate (porcine, caprine, and ovine) and canine species that are the focus of this review. The overriding caveat to using large lower-order species is to take the time in advance to understand and appreciate the limitations and strengths of each animal model. Under these circumstances, experiments can be strategically designed to optimize the potential of an animal to develop the cardinal features of postmenopausal bone loss and/or yield information of relevance to treatment.

Original languageEnglish
Pages (from-to)1353-1368
Number of pages16
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume23
Issue number9
DOIs
StatePublished - 2008

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Primates
Osteoporosis
Animal Models
Research
Postmenopausal Osteoporosis
Canidae
Sheep
Swine
Research Personnel
Costs and Cost Analysis

Keywords

  • Animal models
  • Estradiol
  • Estrus
  • Micro-livestock
  • Osteoporosis
  • Postmenopause

ASJC Scopus subject areas

  • Surgery

Cite this

Review of nonprimate, large animal models for osteoporosis research. / Reinwald, Susan; Burr, David.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 23, No. 9, 2008, p. 1353-1368.

Research output: Contribution to journalArticle

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