Review of risk factors in calcium oxalate urolithiasis

W. G. Robertson, Munro Peacock

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Calcium stone disease in the urinary tract is due to the formation of excessively large crystals and aggregates of calcium salts in urine. This phenomenon, in turn, is due to the combination of abnormalities in a number of potential urinary risk factors for the disorder. These include supersaturation-determining factors such as hypercalciuria, mild and severe hyperoxaluria, a persistently alkaline urine and a low urine volume; a reduced excretion of certain polyanionic inhibitors of crystallization of calcium oxalate, in particular glycosaminoglycans, RNA, and Tamm-Horsfall mucoprotein; and an increased excretion of certain promoters of crystallization such as urate and, perhaps, polymerized uromucoid. In turn, abnormalities in these urinary risk factors may be aggravated by or attributed to a number of epidemiological factors such as the age and sex of the individual, climate, season, stress, level of affluence, dietary and fluid intake and various metabolic and genetic disorders such as primary hyperparathyroidism, renal tubular acidosis and hereditary and enteric hyperoxaluria.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalWorld Journal of Urology
Volume1
Issue number3
DOIs
StatePublished - Aug 1983
Externally publishedYes

Fingerprint

Hyperoxaluria
Urine
Crystallization
Mucoproteins
Uromodulin
Renal Tubular Acidosis
Calcium
Urologic Diseases
Hypercalciuria
Calcium Oxalate
Inborn Genetic Diseases
Primary Hyperparathyroidism
Glycosaminoglycans
Uric Acid
Climate
Salts
RNA
Calcium Oxalate Nephrolithiasis

ASJC Scopus subject areas

  • Urology

Cite this

Review of risk factors in calcium oxalate urolithiasis. / Robertson, W. G.; Peacock, Munro.

In: World Journal of Urology, Vol. 1, No. 3, 08.1983, p. 114-118.

Research output: Contribution to journalArticle

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