Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function

Lucas Carvalho, Jie Sun, Colleen Kane, Fraser Marshall, Connie Krawczyk, Edward J. Pearce

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Dendritic cells (DCs) play a central role in activating CD4 T (T helper, Th) cells. As a component of their response to pathogen-associated stimuli, DCs produce cytokines and express surface molecules that provide important cues to modulate the effector functions of responding Th cells. Much is known of how DCs respond to, and influence immune response outcome to, bacterial and viral pathogens. However, relatively little is understood about how DCs respond to helminth parasites. This is an area of considerable interest since it impacts our understanding of the initiation of Th2 responses, which are stereotypically associated with helminth infections, and the regulation of allergic and autoimmune pathologies which evidence suggests are less severe or absent in individuals infected with helminths. This review attempts to summarize our understanding of the effects of helminth products on dendritic cell biology.

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalImmunology
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Dendritic cell
  • Helminth pathogens
  • Immunoregulation
  • T helper type 1 (Th1)/Th2
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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