Rhabdomyosarcoma in children

A SEER population based study

Eduardo A. Perez, Noor Kassira, Michael C. Cheung, Leonidas Koniaris, Holly L. Neville, Juan E. Sola

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objective: To examine incidence and outcomes for pediatric rhabdomyosarcoma (RMS). Methods: The SEER registry was examined for patients with RMS <20 y old. Results: Overall, 1544 patients were identified for an incidence of 0.4414/100,000 per year. Males outnumbered females 3:2. Tumors were classified as embryonal (67%), alveolar (32%), and pleomorphic (1%). Alveolar and pleomorphic RMS were more common in adolescents, whereas embryonal type was more common in younger children (P = 0.0001). Pleomorphic (47%) and alveolar (39%) RMS commonly presented with distant disease, in contrast to embryonal (25%). Most patients had surgical resection (81%) and radiotherapy (63%). Overall, 5- and 10-y survival was 60% and 57%, respectively. Univariate analysis identified higher survival for age <10 y, local stage, favorable site, embryonal type,

Original languageEnglish (US)
JournalJournal of Surgical Research
Volume170
Issue number2
DOIs
StatePublished - Oct 2011
Externally publishedYes

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Rhabdomyosarcoma
Alveolar Rhabdomyosarcoma
Population
Survival
Incidence
Registries
Radiotherapy
Pediatrics
Neoplasms

Keywords

  • outcomes studies
  • pediatrics
  • rhabdomyosarcoma
  • SEER

ASJC Scopus subject areas

  • Surgery

Cite this

Rhabdomyosarcoma in children : A SEER population based study. / Perez, Eduardo A.; Kassira, Noor; Cheung, Michael C.; Koniaris, Leonidas; Neville, Holly L.; Sola, Juan E.

In: Journal of Surgical Research, Vol. 170, No. 2, 10.2011.

Research output: Contribution to journalArticle

Perez, Eduardo A. ; Kassira, Noor ; Cheung, Michael C. ; Koniaris, Leonidas ; Neville, Holly L. ; Sola, Juan E. / Rhabdomyosarcoma in children : A SEER population based study. In: Journal of Surgical Research. 2011 ; Vol. 170, No. 2.
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