Rho and axonal regeneration in the central nervous system

Pan Pan Yu, Xiao Ming Xu, Pei Hua Lu

Research output: Contribution to journalReview article

Abstract

Rho is a member of the Rho family of small GTPase, and acts as a molecular switch in some signal transduction pathway. Rho can induce growth cones collapse and inhibit axonal outgrowth by regulating the actin cytoskeleton. Recent studies have indicated that three myelin-derived inhibitors including Nogo-A, MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
JournalProgress in Biochemistry and Biophysics
Volume31
Issue number4
StatePublished - Apr 1 2004

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Keywords

  • Growth cone
  • Rho
  • Rho-associated kinase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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