Rho is a member of the Rho family of small GTPase, and acts as a molecular switch in some signal transduction pathway. Rho can induce growth cones collapse and inhibit axonal outgrowth by regulating the actin cytoskeleton. Recent studies have indicated that three myelin-derived inhibitors including Nogo-A, MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway.
|Original language||English (US)|
|Number of pages||3|
|Journal||Progress in Biochemistry and Biophysics|
|State||Published - Apr 1 2004|
- Growth cone
- Rho-associated kinase
ASJC Scopus subject areas