Rho and axonal regeneration in the central nervous system

Pan Pan Yu, Xiao-Ming Xu, Pei Hua Lu

Research output: Contribution to journalArticle

Abstract

Rho is a member of the Rho family of small GTPase, and acts as a molecular switch in some signal transduction pathway. Rho can induce growth cones collapse and inhibit axonal outgrowth by regulating the actin cytoskeleton. Recent studies have indicated that three myelin-derived inhibitors including Nogo-A, MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
JournalProgress in Biochemistry and Biophysics
Volume31
Issue number4
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Signal transduction
Neurology
Regeneration
Signal Transduction
Central Nervous System
Growth Cones
Monomeric GTP-Binding Proteins
Myelin Sheath
Actin Cytoskeleton
Cones
Actins
Switches

Keywords

  • Growth cone
  • Rho
  • Rho-associated kinase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Rho and axonal regeneration in the central nervous system. / Yu, Pan Pan; Xu, Xiao-Ming; Lu, Pei Hua.

In: Progress in Biochemistry and Biophysics, Vol. 31, No. 4, 04.2004, p. 296-298.

Research output: Contribution to journalArticle

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