Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins

Role of heredity

Tammy M. Seasholtz, Jennifer Wessel, Fangwen Rao, Brinda K. Rana, Srikrishna Khandrika, Brian P. Kennedy, Elizabeth O. Lillie, Michael G. Ziegler, Douglas W. Smith, Nicholas J. Schork, Joan Heller Brown, Daniel T. O'Connor

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The Rho/Rho kinase (ROCK) pathway is implicated in experimental hypertension. We, therefore, explored the role of ROCK2 genetic variation in human blood pressure (BP) regulation, exploiting the advantages of a human twin sample to probe heritability. The focus of this work is the common nonsynonymous variant at ROCK2: Thr431Asn. Cardiovascular and autonomic traits displayed substantial heritability (from ≈33% to 71%; P

Original languageEnglish (US)
Pages (from-to)937-947
Number of pages11
JournalHypertension
Volume47
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

rho-Associated Kinases
Heredity
Vascular Resistance
Blood Pressure
Hypertension

Keywords

  • Blood pressure
  • Hypertension, renal
  • Renin
  • Vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins : Role of heredity. / Seasholtz, Tammy M.; Wessel, Jennifer; Rao, Fangwen; Rana, Brinda K.; Khandrika, Srikrishna; Kennedy, Brian P.; Lillie, Elizabeth O.; Ziegler, Michael G.; Smith, Douglas W.; Schork, Nicholas J.; Brown, Joan Heller; O'Connor, Daniel T.

In: Hypertension, Vol. 47, No. 5, 05.2006, p. 937-947.

Research output: Contribution to journalArticle

Seasholtz, TM, Wessel, J, Rao, F, Rana, BK, Khandrika, S, Kennedy, BP, Lillie, EO, Ziegler, MG, Smith, DW, Schork, NJ, Brown, JH & O'Connor, DT 2006, 'Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: Role of heredity', Hypertension, vol. 47, no. 5, pp. 937-947. https://doi.org/10.1161/01.HYP.0000217364.45622.f0
Seasholtz, Tammy M. ; Wessel, Jennifer ; Rao, Fangwen ; Rana, Brinda K. ; Khandrika, Srikrishna ; Kennedy, Brian P. ; Lillie, Elizabeth O. ; Ziegler, Michael G. ; Smith, Douglas W. ; Schork, Nicholas J. ; Brown, Joan Heller ; O'Connor, Daniel T. / Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins : Role of heredity. In: Hypertension. 2006 ; Vol. 47, No. 5. pp. 937-947.
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