RhoA/Rho kinase in spinal cord injury

Xiangbing Wu, Xiao-Ming Xu

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A spinal cord injury refers to an injury to the spinal cord that is caused by a trauma instead of diseases. Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation, excitotoxicity, and cell death. During the secondary injury, many signal pathways are activated and play important roles in mediating the pathogenesis of spinal cord injury. Among them, the RhoA/Rho kinase pathway plays a particular role in mediating spinal degeneration and regeneration. In this review, we will discuss the role and mechanism of RhoA/Rho kinase-mediated spinal cord pathogenesis, as well as the potential of targeting RhoA/Rho kinase as a strategy for promoting both neuroprotection and axonal regeneration.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalNeural Regeneration Research
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cell death
  • Degeneration
  • Inflammation
  • Regeneration
  • Rho kinase
  • RhoA
  • Spinal cord injury

ASJC Scopus subject areas

  • Developmental Neuroscience

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