Ribose-modified mizoribine analogues: Synthesis and biological evaluation

Palmarisa Franchetti, Michela Pasqualini, Loredana Cappellacci, Riccardo Petrelli, Patrizia Vita, Mario Grifantini, Hiremagalur N. Jayaram

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

□ Synthesis, conformational analysis and antitumor evaluation of 2′- and 3′-C-methyl analogues of mizoribine (bredinine, 4-carbamoyl-1-β-D-ribofuranosylimidazole-5-olate) are reported.

Original languageEnglish (US)
Pages (from-to)2023-2027
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number10-12
DOIs
StatePublished - Sep 1 2005

Keywords

  • Antitumor agents
  • IMPDH inhibitors
  • Mizoribine analogues

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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