Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Thomas J. Delia, A. Nagarajan, Sherry Queener, Marilyn S. Bartlet

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture.

Original languageEnglish (US)
Pages (from-to)2367-2370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number19
DOIs
StatePublished - Oct 8 1996
Externally publishedYes

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Pentamidine
Benzene
Pneumonia
Molecules
pyridine
pyrimidine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Ring-based analogues of pentamidine versus P. carinii pneumonia in culture. / Delia, Thomas J.; Nagarajan, A.; Queener, Sherry; Bartlet, Marilyn S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 19, 08.10.1996, p. 2367-2370.

Research output: Contribution to journalArticle

Delia, Thomas J. ; Nagarajan, A. ; Queener, Sherry ; Bartlet, Marilyn S. / Ring-based analogues of pentamidine versus P. carinii pneumonia in culture. In: Bioorganic and Medicinal Chemistry Letters. 1996 ; Vol. 6, No. 19. pp. 2367-2370.
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