Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Thomas J. Delia, A. Nagarajan, Sherry F. Queener, Marilyn S. Bartlet

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture.

Original languageEnglish (US)
Pages (from-to)2367-2370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number19
DOIs
StatePublished - Oct 8 1996

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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