Risk-based prostate cancer screening: Who and how?

Allison S. Glass, K. Clint Cary, Matthew R. Cooperberg

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The purpose of this review is to identify clinical risk factors for prostate cancer and to assess the utility and limitations of our current tools for prostate cancer screening. Prostate-specific antigen is the single most important factor for identifying men at increased risk of prostate cancer but is best assessed in the context of other clinical factors; increasing age, race, and family history are well-established risk factors for the diagnosis of prostate cancer. In addition to clinical risk calculators, novel tools such as multiparametric imaging, serum or urinary biomarkers, and genetic profiling show promise in improving prostate cancer diagnosis and characterization. Optimal use of existing and future tools will help alleviate the problems of overdiagnosis and overtreatment of low-risk prostate cancer without reversing the substantial mortality declines that have been achieved in the screening era.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalCurrent Urology Reports
Volume14
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Clinical risk
  • Prostate cancer
  • Prostate-specific antigen
  • Risk-based
  • Screening tools

ASJC Scopus subject areas

  • Urology

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