Risk Factors for Acquiring Pneumococcal Infections

Benjamin A. Lipsky, Edward J. Boyko, Thomas Inui, Thomas D. Koepsell

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

• To identify risk factors for developing pneumococcal infections, we carried out a case-controlled study on a retrospectively constituted cohort of 3074 clinic patients in a presumed high-risk population. Culture-proved pneumococcal infections were identified in 63 men over a period of 5.5 years, yielding an estimated incidence of 6.3 cases per 1000 person-years. By comparing these patients with 130 uninfected control patients, the relative risk of pneumococcal infections related to various exposures was calculated by logistic regression analysis. Statistically significant independent risk factors (and their relative risks) were as follows: dementia (5.82), seizure disorders (4.38), current cigarette smoking (4.00), congestive heart failure (3.83), cerebrovascular disease (3.82), institutionalization (3.13), and chronic obstructive pulmonary disease (2.38). Risk was increased with age and previous hospitalizations, and, to a nonsignificant degree, by hotel residence (3.93), lung cancer (2.24), previous smoking (2.14), corticosteroid use (1.81), and alcoholism (1.35); but not by diabetes mellitus (0.99), nonlung malignancies (0.93), nonwhite race (0.89), or ischemic heart disease (0.58).

Original languageEnglish (US)
Pages (from-to)2179-2185
Number of pages7
JournalArchives of Internal Medicine
Volume146
Issue number11
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Pneumococcal Infections
Smoking
Cerebrovascular Disorders
Institutionalization
Chronic Obstructive Pulmonary Disease
Alcoholism
Myocardial Ischemia
Dementia
Epilepsy
Lung Neoplasms
Diabetes Mellitus
Adrenal Cortex Hormones
Hospitalization
Heart Failure
Logistic Models
Regression Analysis
Incidence
Population
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Risk Factors for Acquiring Pneumococcal Infections. / Lipsky, Benjamin A.; Boyko, Edward J.; Inui, Thomas; Koepsell, Thomas D.

In: Archives of Internal Medicine, Vol. 146, No. 11, 1986, p. 2179-2185.

Research output: Contribution to journalArticle

Lipsky, Benjamin A. ; Boyko, Edward J. ; Inui, Thomas ; Koepsell, Thomas D. / Risk Factors for Acquiring Pneumococcal Infections. In: Archives of Internal Medicine. 1986 ; Vol. 146, No. 11. pp. 2179-2185.
@article{cacf639661c14604935390b43a9a69e2,
title = "Risk Factors for Acquiring Pneumococcal Infections",
abstract = "• To identify risk factors for developing pneumococcal infections, we carried out a case-controlled study on a retrospectively constituted cohort of 3074 clinic patients in a presumed high-risk population. Culture-proved pneumococcal infections were identified in 63 men over a period of 5.5 years, yielding an estimated incidence of 6.3 cases per 1000 person-years. By comparing these patients with 130 uninfected control patients, the relative risk of pneumococcal infections related to various exposures was calculated by logistic regression analysis. Statistically significant independent risk factors (and their relative risks) were as follows: dementia (5.82), seizure disorders (4.38), current cigarette smoking (4.00), congestive heart failure (3.83), cerebrovascular disease (3.82), institutionalization (3.13), and chronic obstructive pulmonary disease (2.38). Risk was increased with age and previous hospitalizations, and, to a nonsignificant degree, by hotel residence (3.93), lung cancer (2.24), previous smoking (2.14), corticosteroid use (1.81), and alcoholism (1.35); but not by diabetes mellitus (0.99), nonlung malignancies (0.93), nonwhite race (0.89), or ischemic heart disease (0.58).",
author = "Lipsky, {Benjamin A.} and Boyko, {Edward J.} and Thomas Inui and Koepsell, {Thomas D.}",
year = "1986",
doi = "10.1001/archinte.1986.00360230105016",
language = "English (US)",
volume = "146",
pages = "2179--2185",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Risk Factors for Acquiring Pneumococcal Infections

AU - Lipsky, Benjamin A.

AU - Boyko, Edward J.

AU - Inui, Thomas

AU - Koepsell, Thomas D.

PY - 1986

Y1 - 1986

N2 - • To identify risk factors for developing pneumococcal infections, we carried out a case-controlled study on a retrospectively constituted cohort of 3074 clinic patients in a presumed high-risk population. Culture-proved pneumococcal infections were identified in 63 men over a period of 5.5 years, yielding an estimated incidence of 6.3 cases per 1000 person-years. By comparing these patients with 130 uninfected control patients, the relative risk of pneumococcal infections related to various exposures was calculated by logistic regression analysis. Statistically significant independent risk factors (and their relative risks) were as follows: dementia (5.82), seizure disorders (4.38), current cigarette smoking (4.00), congestive heart failure (3.83), cerebrovascular disease (3.82), institutionalization (3.13), and chronic obstructive pulmonary disease (2.38). Risk was increased with age and previous hospitalizations, and, to a nonsignificant degree, by hotel residence (3.93), lung cancer (2.24), previous smoking (2.14), corticosteroid use (1.81), and alcoholism (1.35); but not by diabetes mellitus (0.99), nonlung malignancies (0.93), nonwhite race (0.89), or ischemic heart disease (0.58).

AB - • To identify risk factors for developing pneumococcal infections, we carried out a case-controlled study on a retrospectively constituted cohort of 3074 clinic patients in a presumed high-risk population. Culture-proved pneumococcal infections were identified in 63 men over a period of 5.5 years, yielding an estimated incidence of 6.3 cases per 1000 person-years. By comparing these patients with 130 uninfected control patients, the relative risk of pneumococcal infections related to various exposures was calculated by logistic regression analysis. Statistically significant independent risk factors (and their relative risks) were as follows: dementia (5.82), seizure disorders (4.38), current cigarette smoking (4.00), congestive heart failure (3.83), cerebrovascular disease (3.82), institutionalization (3.13), and chronic obstructive pulmonary disease (2.38). Risk was increased with age and previous hospitalizations, and, to a nonsignificant degree, by hotel residence (3.93), lung cancer (2.24), previous smoking (2.14), corticosteroid use (1.81), and alcoholism (1.35); but not by diabetes mellitus (0.99), nonlung malignancies (0.93), nonwhite race (0.89), or ischemic heart disease (0.58).

UR - http://www.scopus.com/inward/record.url?scp=84941814368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941814368&partnerID=8YFLogxK

U2 - 10.1001/archinte.1986.00360230105016

DO - 10.1001/archinte.1986.00360230105016

M3 - Article

C2 - 3778047

AN - SCOPUS:84941814368

VL - 146

SP - 2179

EP - 2185

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 11

ER -