Risk factors for drug-induced liver disease

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Variables that predispose individuals to develop idiosyncratic drug-induced liver injury (DILI) can be categorized into genetic and nongenetic risk factors. Nongenetic risk factors, which are the subject of this chapter, can be broadly categorized into host-related factors, environmental factors, and compound characteristics. Various host factors such as age, gender, and pregnancy; comorbidities such as obesity, diabetes, and underlying liver disease; and underlying nutritional status are associated with increased risk of liver injury due to selected compounds, rather than all-cause DILI. Environmental factors such as alcohol consumption may be associated with increased risk from specific compounds such as halothane, isoniazid, methotrexate, and highly active antiretroviral therapy. Although smoking has demonstrable effects on various drug-metabolizing enzymes, there is no evidence to suggest that smoking is associated with increased susceptibility to DILI in humans. Various compound characteristics such as daily dose, drug interactions, metabolic profile, and polypharmacy have been explored as risk factors for DILI in humans, but their overall impact on the risk to develop DILI appears rather modest.

Original languageEnglish (US)
Title of host publicationDrug-Induced Liver Disease
PublisherElsevier Inc.
Pages265-274
Number of pages10
ISBN (Print)9780123878175
DOIs
StatePublished - Aug 27 2013

Keywords

  • Alcohol consumption
  • Daily dose
  • Drug-induced liver injury
  • Polypharmacy
  • Risk factors

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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