Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study

Kathleen E. Corey, Samer Gawrieh, Andrew S. deLemos, Hui Zheng, Andrew E. Scanga, Jennifer W. Haglund, Jorge Sanchez, Christopher J. Danford, Megan Comerford, Krista Bossi, Samina Munir, Naga Chalasani, Julia Wattacheril

Research output: Contribution to journalArticle

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Abstract

AIM To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis. METHODS We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls). RESULTS Ninety-four cases and 150 controls were included. Cases were significantly more likely to be male than controls (67% vs 45%, P < 0.001) and of older age (61.9 years vs 58 years, P = 0.002). In addition, cases were more likely to have had complications of end stage liver disease (83% vs 71%, P = 0.032). On multivariate analysis, the strongest association with the presence of HCC were male gender (OR 4.3, 95%CI: 1.83-10.3, P = 0.001) and age (OR = 1.082, 95%CI: 1.03-1.13, P = 0.001). Hispanic ethnicity was associated with a decreased prevalence of HCC (OR = 0.3, 95%CI: 0.09-0.994, P = 0.048). HCC was predominantly in the form of a single lesion with regional lymph node(s) and distant metastasis in only 2.6% and 6.3%, respectively. Fifty-nine point three percent of individuals with HCC underwent locoregional therapy and 61.5% underwent liver transplantation for HCC. CONCLUSION Male gender, increased age and non-Hispanic ethnicity are associated with HCC in NASH cirrhosis. NASH cirrhosis associated HCC in this cohort was characterized by early stage disease at diagnosis and treatment with locoregional therapy and transplant.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalWorld Journal of Hepatology
Volume9
Issue number7
DOIs
StatePublished - 2017

Fingerprint

Case-Control Studies
Hepatocellular Carcinoma
Fibrosis
Transplants
Non-alcoholic Fatty Liver Disease
End Stage Liver Disease
Therapeutics
Hispanic Americans
Liver Transplantation
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Liver
Neoplasms

Keywords

  • Cirrhosis
  • Ethnicity
  • Gender
  • Hepatocellular carcinoma
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Hepatology

Cite this

Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease : A multicenter, case-control study. / Corey, Kathleen E.; Gawrieh, Samer; deLemos, Andrew S.; Zheng, Hui; Scanga, Andrew E.; Haglund, Jennifer W.; Sanchez, Jorge; Danford, Christopher J.; Comerford, Megan; Bossi, Krista; Munir, Samina; Chalasani, Naga; Wattacheril, Julia.

In: World Journal of Hepatology, Vol. 9, No. 7, 2017, p. 385-390.

Research output: Contribution to journalArticle

Corey, KE, Gawrieh, S, deLemos, AS, Zheng, H, Scanga, AE, Haglund, JW, Sanchez, J, Danford, CJ, Comerford, M, Bossi, K, Munir, S, Chalasani, N & Wattacheril, J 2017, 'Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study', World Journal of Hepatology, vol. 9, no. 7, pp. 385-390. https://doi.org/10.4254/wjh. v9. i7.385
Corey, Kathleen E. ; Gawrieh, Samer ; deLemos, Andrew S. ; Zheng, Hui ; Scanga, Andrew E. ; Haglund, Jennifer W. ; Sanchez, Jorge ; Danford, Christopher J. ; Comerford, Megan ; Bossi, Krista ; Munir, Samina ; Chalasani, Naga ; Wattacheril, Julia. / Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease : A multicenter, case-control study. In: World Journal of Hepatology. 2017 ; Vol. 9, No. 7. pp. 385-390.
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title = "Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study",
abstract = "AIM To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis. METHODS We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls). RESULTS Ninety-four cases and 150 controls were included. Cases were significantly more likely to be male than controls (67{\%} vs 45{\%}, P < 0.001) and of older age (61.9 years vs 58 years, P = 0.002). In addition, cases were more likely to have had complications of end stage liver disease (83{\%} vs 71{\%}, P = 0.032). On multivariate analysis, the strongest association with the presence of HCC were male gender (OR 4.3, 95{\%}CI: 1.83-10.3, P = 0.001) and age (OR = 1.082, 95{\%}CI: 1.03-1.13, P = 0.001). Hispanic ethnicity was associated with a decreased prevalence of HCC (OR = 0.3, 95{\%}CI: 0.09-0.994, P = 0.048). HCC was predominantly in the form of a single lesion with regional lymph node(s) and distant metastasis in only 2.6{\%} and 6.3{\%}, respectively. Fifty-nine point three percent of individuals with HCC underwent locoregional therapy and 61.5{\%} underwent liver transplantation for HCC. CONCLUSION Male gender, increased age and non-Hispanic ethnicity are associated with HCC in NASH cirrhosis. NASH cirrhosis associated HCC in this cohort was characterized by early stage disease at diagnosis and treatment with locoregional therapy and transplant.",
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T1 - Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease

T2 - A multicenter, case-control study

AU - Corey, Kathleen E.

AU - Gawrieh, Samer

AU - deLemos, Andrew S.

AU - Zheng, Hui

AU - Scanga, Andrew E.

AU - Haglund, Jennifer W.

AU - Sanchez, Jorge

AU - Danford, Christopher J.

AU - Comerford, Megan

AU - Bossi, Krista

AU - Munir, Samina

AU - Chalasani, Naga

AU - Wattacheril, Julia

PY - 2017

Y1 - 2017

N2 - AIM To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis. METHODS We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls). RESULTS Ninety-four cases and 150 controls were included. Cases were significantly more likely to be male than controls (67% vs 45%, P < 0.001) and of older age (61.9 years vs 58 years, P = 0.002). In addition, cases were more likely to have had complications of end stage liver disease (83% vs 71%, P = 0.032). On multivariate analysis, the strongest association with the presence of HCC were male gender (OR 4.3, 95%CI: 1.83-10.3, P = 0.001) and age (OR = 1.082, 95%CI: 1.03-1.13, P = 0.001). Hispanic ethnicity was associated with a decreased prevalence of HCC (OR = 0.3, 95%CI: 0.09-0.994, P = 0.048). HCC was predominantly in the form of a single lesion with regional lymph node(s) and distant metastasis in only 2.6% and 6.3%, respectively. Fifty-nine point three percent of individuals with HCC underwent locoregional therapy and 61.5% underwent liver transplantation for HCC. CONCLUSION Male gender, increased age and non-Hispanic ethnicity are associated with HCC in NASH cirrhosis. NASH cirrhosis associated HCC in this cohort was characterized by early stage disease at diagnosis and treatment with locoregional therapy and transplant.

AB - AIM To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis. METHODS We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls). RESULTS Ninety-four cases and 150 controls were included. Cases were significantly more likely to be male than controls (67% vs 45%, P < 0.001) and of older age (61.9 years vs 58 years, P = 0.002). In addition, cases were more likely to have had complications of end stage liver disease (83% vs 71%, P = 0.032). On multivariate analysis, the strongest association with the presence of HCC were male gender (OR 4.3, 95%CI: 1.83-10.3, P = 0.001) and age (OR = 1.082, 95%CI: 1.03-1.13, P = 0.001). Hispanic ethnicity was associated with a decreased prevalence of HCC (OR = 0.3, 95%CI: 0.09-0.994, P = 0.048). HCC was predominantly in the form of a single lesion with regional lymph node(s) and distant metastasis in only 2.6% and 6.3%, respectively. Fifty-nine point three percent of individuals with HCC underwent locoregional therapy and 61.5% underwent liver transplantation for HCC. CONCLUSION Male gender, increased age and non-Hispanic ethnicity are associated with HCC in NASH cirrhosis. NASH cirrhosis associated HCC in this cohort was characterized by early stage disease at diagnosis and treatment with locoregional therapy and transplant.

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KW - Ethnicity

KW - Gender

KW - Hepatocellular carcinoma

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