Risk factors for incident Alzheimer's disease in African Americans and Yoruba

A. Ogunniyi, Kathleen Hall, O. Gureje, O. Baiyewu, Sujuan Gao, Frederick Unverzagt, V. Smith-Gamble, R. E. Evans, J. Dickens, B. S. Musick, Hugh Hendrie

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Introduction: The incidence rate of Alzheimer's disease (AD) was found to be 2 times lower in Yoruba than in African Americans. This study was aimed at identifying the factors associated with increased risk of incident AD in the two communities. Methodology: A two-stage design with initial screening using the CSI'D followed by neuropsychological test battery, relations' interview and physician assessment in a sub-sample. NINCDS-ADRDA criteria were met for AD. The risk factor variables assessed included demographic, lifestyle, medical and family history items. Results: In the Yoruba, AD was associated with age (OR = 1.07) and female gender (OR = 2.93). In African Americans, age (OR = 1.09) and rural living (OR = 2.08) were the significant risk factors, while alcohol was protective (OR = 0.49). Discussion: Age was a significant risk factor for AD at both sites. The higher risk of incident AD in the Yoruba female, and in African Americans who resided in rural areas in childhood were similar with the prevalence cases. Alcohol emerged a protective factor in African Americans. More studies are required, including biological measurements, to adequately explain the differences in rates.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalMetabolic Brain Disease
Volume21
Issue number2-3
DOIs
StatePublished - Sep 2006

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African Americans
Alzheimer Disease
Medical History Taking
Alcohols
Neuropsychological Tests
Life Style
Screening
Demography
Interviews
Physicians
Incidence

Keywords

  • Alzheimer's disease
  • Cross-cultural study
  • Incidence
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Biochemistry
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)

Cite this

Risk factors for incident Alzheimer's disease in African Americans and Yoruba. / Ogunniyi, A.; Hall, Kathleen; Gureje, O.; Baiyewu, O.; Gao, Sujuan; Unverzagt, Frederick; Smith-Gamble, V.; Evans, R. E.; Dickens, J.; Musick, B. S.; Hendrie, Hugh.

In: Metabolic Brain Disease, Vol. 21, No. 2-3, 09.2006, p. 235-240.

Research output: Contribution to journalArticle

Ogunniyi, A, Hall, K, Gureje, O, Baiyewu, O, Gao, S, Unverzagt, F, Smith-Gamble, V, Evans, RE, Dickens, J, Musick, BS & Hendrie, H 2006, 'Risk factors for incident Alzheimer's disease in African Americans and Yoruba', Metabolic Brain Disease, vol. 21, no. 2-3, pp. 235-240. https://doi.org/10.1007/s11011-006-9017-2
Ogunniyi, A. ; Hall, Kathleen ; Gureje, O. ; Baiyewu, O. ; Gao, Sujuan ; Unverzagt, Frederick ; Smith-Gamble, V. ; Evans, R. E. ; Dickens, J. ; Musick, B. S. ; Hendrie, Hugh. / Risk factors for incident Alzheimer's disease in African Americans and Yoruba. In: Metabolic Brain Disease. 2006 ; Vol. 21, No. 2-3. pp. 235-240.
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