Risk factors for native kidney dysfunction in patients with abdominal multivisceral/small bowel transplantation

M. Suzuki, M. A. Mujtaba, Asif Sharfuddin, Muhammad Yaqub, D. P. Mishler, S. Faiz, R. M. Vianna, Richard Mangus, J. A. Tector, Tim Taber

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Kidney dysfunction is a recognized complication after non-renal solid organ transplantation, particularly after intestinal transplant. In our study, we reviewed data on 33 multivisceral transplant (MVT)- and 15 isolated small bowel (ISB)-transplant patients to determine risk factors for kidney dysfunction. Kidney function was estimated by modified diet in renal disease (MDRD) and Schwartz formula for adults and children, respectively. Acute kidney injury (AKI) was defined as an increase in the serum Cr (sCr) greater than twofold. Kidney function declined significantly at one yr after transplantation with 46% of subjects showing an estimated GFR (eGFR) <60 mL/min. Patients with an episode of AKI were more likely to have reduced eGFR than those without AKI (p < 0.025). In linear regression analyses, age, pre-transplant sCr, eGFR at postoperative day (POD) 30, 90, 180, 270, and tacrolimus level at POD 7 showed significant correlation with one yr post-transplant eGFR (p < 0.05). Pediatric patients and patients with MVT had lesser decline in kidney function compared with adults or patients with ISB. In conclusion, risk factors for post-transplant kidney dysfunction in intestinal transplantation included age, pre-transplant sCr, AKI episode, eGFR at POD 30, 90, 180, 270, and tacrolimus level at POD 7.

Original languageEnglish
JournalClinical Transplantation
Volume26
Issue number4
DOIs
StatePublished - Jul 2012

Fingerprint

Transplantation
Transplants
Kidney
Acute Kidney Injury
Tacrolimus
Serum
Organ Transplantation
Linear Models
Regression Analysis
Pediatrics
Diet

Keywords

  • Calcineurin inhibitor toxicity
  • Intestinal transplant
  • Kidney disease
  • Kidney function
  • Kidney injury

ASJC Scopus subject areas

  • Transplantation

Cite this

Risk factors for native kidney dysfunction in patients with abdominal multivisceral/small bowel transplantation. / Suzuki, M.; Mujtaba, M. A.; Sharfuddin, Asif; Yaqub, Muhammad; Mishler, D. P.; Faiz, S.; Vianna, R. M.; Mangus, Richard; Tector, J. A.; Taber, Tim.

In: Clinical Transplantation, Vol. 26, No. 4, 07.2012.

Research output: Contribution to journalArticle

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AB - Kidney dysfunction is a recognized complication after non-renal solid organ transplantation, particularly after intestinal transplant. In our study, we reviewed data on 33 multivisceral transplant (MVT)- and 15 isolated small bowel (ISB)-transplant patients to determine risk factors for kidney dysfunction. Kidney function was estimated by modified diet in renal disease (MDRD) and Schwartz formula for adults and children, respectively. Acute kidney injury (AKI) was defined as an increase in the serum Cr (sCr) greater than twofold. Kidney function declined significantly at one yr after transplantation with 46% of subjects showing an estimated GFR (eGFR) <60 mL/min. Patients with an episode of AKI were more likely to have reduced eGFR than those without AKI (p < 0.025). In linear regression analyses, age, pre-transplant sCr, eGFR at postoperative day (POD) 30, 90, 180, 270, and tacrolimus level at POD 7 showed significant correlation with one yr post-transplant eGFR (p < 0.05). Pediatric patients and patients with MVT had lesser decline in kidney function compared with adults or patients with ISB. In conclusion, risk factors for post-transplant kidney dysfunction in intestinal transplantation included age, pre-transplant sCr, AKI episode, eGFR at POD 30, 90, 180, 270, and tacrolimus level at POD 7.

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