Risk factors for skin cancers: A nested case-control study within the Nurses' Health Study

Jiali Han, Graham A. Colditz, David J. Hunter

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Background: Constitutional factors and sun exposure are associated with skin cancer risk. However, these relations are complex and differ according to skin cancer type. Methods: We examined the associations of constitutional risk factors and sun exposure with the risks of three types of skin cancer simultaneously and evaluated the interaction between constitutional susceptibility and sun exposure in a nested case-control study within the Nurses' Health Study [200 melanoma, 275 squamous cell carcinoma (SCC), and 283 basal cell carcinoma (BCC) cases, and 804 controls]. Information regarding skin cancer risk factors was obtained from the retrospective supplementary questionnaire. Results: Constitutional susceptibility was an independent risk factor for all three types of skin cancer. Sunlamp usage or tanning salon attendance was a risk factor for melanoma after adjusting for potential confounding variables (OR for ever vs never usage, 2.06, 95% CI 1.30-3.26). Higher sun exposure while wearing a bathing suit was an independent risk factor for all three types of skin cancer. We observed a significant interaction between constitutional susceptibility and sun exposure while wearing a bathing suit on melanoma risk (P, interaction, 0.03); women with the highest susceptibility and highest exposure had an OR of 8.37 (95% CI 3.07-22.84). This interaction was weaker and non-significant for SCC and BCC. Conclusions: These data largely confirm past studies on risk factors for skin cancer but provide evidence of difference on the strength of these risk factors for melanoma compared with SCC and BCC.

Original languageEnglish (US)
Pages (from-to)1514-1521
Number of pages8
JournalInternational Journal of Epidemiology
Volume35
Issue number6
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Skin Neoplasms
Case-Control Studies
Solar System
Nurses
Health
Melanoma
Basal Cell Carcinoma
Squamous Cell Carcinoma
Tanning
Confounding Factors (Epidemiology)

Keywords

  • Constitutional susceptibility
  • Skin cancer
  • Sun exposure

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Risk factors for skin cancers : A nested case-control study within the Nurses' Health Study. / Han, Jiali; Colditz, Graham A.; Hunter, David J.

In: International Journal of Epidemiology, Vol. 35, No. 6, 01.12.2006, p. 1514-1521.

Research output: Contribution to journalArticle

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