Risk factors, pathophysiology, and treatment of hot flashes in cancer

William I. Fisher, Aimee K. Johnson, Gary R. Elkins, Julie Otte, Debra S. Burns, Menggang Yu, Janet Carpenter

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Answer questions and earn CME/CNE Hot flashes are prevalent and severe symptoms that can interfere with mood, sleep, and quality of life for women and men with cancer. The purpose of this article is to review existing literature on the risk factors, pathophysiology, and treatment of hot flashes in individuals with cancer. Electronic searches were conducted to identify relevant English-language literature published through June 15, 2012. Results indicated that risk factors for hot flashes in cancer include patient-related factors (eg, age, race/ethnicity, educational level, smoking history, cardiovascular risk including body mass index, and genetics) and disease-related factors (eg, cancer diagnosis and dose/type of treatment). In addition, although the pathophysiology of hot flashes has remained elusive, these symptoms are likely attributable to disruptions in thermoregulation and neurochemicals. Therapies that have been offered or tested fall into 4 broad categories: pharmacological, nutraceutical, surgical, and complementary/behavioral strategies. The evidence base for this broad range of therapies varies, with some treatments not yet having been fully tested or showing equivocal results. The evidence base surrounding all therapies is evaluated to enhance hot flash treatment decision-making by clinicians and patients .

Original languageEnglish
Pages (from-to)167-192
Number of pages26
JournalCa-A Cancer Journal for Clinicians
Volume63
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Hot Flashes
Neoplasms
Therapeutics
Inborn Genetic Diseases
Body Temperature Regulation
Age Factors
Dietary Supplements
Decision Making
Sleep
Body Mass Index
Language
Smoking
History
Quality of Life
Pharmacology

Keywords

  • hot flashes
  • menopause
  • neoplasms
  • palliative care
  • sweating

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Risk factors, pathophysiology, and treatment of hot flashes in cancer. / Fisher, William I.; Johnson, Aimee K.; Elkins, Gary R.; Otte, Julie; Burns, Debra S.; Yu, Menggang; Carpenter, Janet.

In: Ca-A Cancer Journal for Clinicians, Vol. 63, No. 3, 05.2013, p. 167-192.

Research output: Contribution to journalArticle

Fisher, William I. ; Johnson, Aimee K. ; Elkins, Gary R. ; Otte, Julie ; Burns, Debra S. ; Yu, Menggang ; Carpenter, Janet. / Risk factors, pathophysiology, and treatment of hot flashes in cancer. In: Ca-A Cancer Journal for Clinicians. 2013 ; Vol. 63, No. 3. pp. 167-192.
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