Risk of Plasmodium falciparum infection during a malaria epidemic in highland Kenya, 1997

Chandy C. John, David K. Koech, P. Odada Sumba, John H. Ouma

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Malaria epidemics in highland areas of East Africa have occurred with increasing frequency since the late 1980s, but the actual risk of Plasmodium falciparum infection in children and adults during these epidemics has not been well characterized. During a malaria epidemic in a highland area of Kenya, risk of infection was assessed in 50 adults (≥18 years old) and 32 children (≤8 years old) after treatment and parasitologic clearance with sulfadoxine-pyrimethamine treatment. Over a 10-week period, 36 of the 82 study participants (43.9%) became infected. The risk of infection was similar in children and adults (hazard ratio for children = 1.21, 95% CI: 0.63-2.33). These findings contrast with the age-related protection from infection reported in areas of stable, intense transmission, and demonstrate that during malaria epidemics, both children and adults in highland areas of Kenya are at high risk of infection.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalActa Tropica
Volume92
Issue number1
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Epidemic
  • Highland
  • Malaria
  • Reinfection
  • Treatment

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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