Risk of ulcerative colitis among former and current cigarette smokers

E. J. Boyko, T. D. Koepsell, D. R. Perera, Thomas Inui

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

We performed a case-control study of the effect of tobacco smoking on the risk of acquiring ulcerative colitis among the 304,000 members of a health maintenance organization. Smoking histories before the date of the onset of ulcerative colitis were compared in 212 cases and an equal number of controls matched for age and sex who were selected from the enrollment file of the health maintenance organization. The relative risk of ulcerative colitis among current cigarette smokers as compared with nonsmokers was 0.6 (95 percent confidence interval, 0.4 to 1.0); however, among former cigarette smokers it was 2.0 (95 percent confidence interval, 1.1 to 3.7). These values remained after adjustment for socioeconomic factors and for coffee and alcohol consumption. The higher risk among former smokers could not be explained by postulating that smokers gave up tobacco near the time of disease onset because of early symptoms of ulcerative colitis. The relative risk of ulcerative colitis among former smokers increased in proportion to the cumulative number of cigarettes smoked before the onset of disease, suggesting a causal relationship between this exposure and disease occurrence. No difference in risk was observed among current smokers according to cumulative amount smoked. We conclude that former and current tobacco use may have opposite effects on the risk of acquiring ulcerative colitis.

Original languageEnglish (US)
Pages (from-to)707-710
Number of pages4
JournalNew England Journal of Medicine
Volume316
Issue number12
StatePublished - 1987
Externally publishedYes

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Ulcerative Colitis
Tobacco Products
Health Maintenance Organizations
Smoking
Confidence Intervals
Coffee
Tobacco Use
Alcohol Drinking
Tobacco
Case-Control Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Boyko, E. J., Koepsell, T. D., Perera, D. R., & Inui, T. (1987). Risk of ulcerative colitis among former and current cigarette smokers. New England Journal of Medicine, 316(12), 707-710.

Risk of ulcerative colitis among former and current cigarette smokers. / Boyko, E. J.; Koepsell, T. D.; Perera, D. R.; Inui, Thomas.

In: New England Journal of Medicine, Vol. 316, No. 12, 1987, p. 707-710.

Research output: Contribution to journalArticle

Boyko, EJ, Koepsell, TD, Perera, DR & Inui, T 1987, 'Risk of ulcerative colitis among former and current cigarette smokers', New England Journal of Medicine, vol. 316, no. 12, pp. 707-710.
Boyko, E. J. ; Koepsell, T. D. ; Perera, D. R. ; Inui, Thomas. / Risk of ulcerative colitis among former and current cigarette smokers. In: New England Journal of Medicine. 1987 ; Vol. 316, No. 12. pp. 707-710.
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