Risk stratification for sudden cardiac death in North America – current perspectives

Alfred E. Buxton, Jonathan W. Waks, Changyu Shen, Peng-Sheng Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sudden cardiac death (SCD) accounts for approximately 360,000 deaths annually in the United States, and is the cause of half of all cardiovascular deaths. In patients with severely depressed left ventricular ejection fraction (LVEF), implantable cardioverter-defibrillators (ICDs) have been shown to significantly reduce total mortality, but many factors beyond LVEF influence the relative benefit afforded by ICD implantation. In fact, among patients with prior myocardial infarction, approximately half of all SCDs occur in patients without severe LV dysfunction, and in analyses of large ICD trials, certain patient subgroups derive no benefit to ICD implantation despite having low LVEF, often due to competing non-arrhythmic mortality. Improved risk stratification tools to help select patients who are likely to derive the most benefit from ICD implantation are therefore needed. This manuscript will review studies evaluating use of ICDs in patients with mild LV systolic dysfunction and LVEF >35%, currently available ICD risk stratification models, and the rationale for designing a cohort study to prospectively validate use of an ICD risk stratification score.

Original languageEnglish (US)
Pages (from-to)817-823
Number of pages7
JournalJournal of Electrocardiology
Volume49
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Implantable Defibrillators
Sudden Cardiac Death
North America
Stroke Volume
Mortality
Cohort Studies
Myocardial Infarction

Keywords

  • Implantable cardioverter-defibrillator
  • Risk stratification
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Risk stratification for sudden cardiac death in North America – current perspectives. / Buxton, Alfred E.; Waks, Jonathan W.; Shen, Changyu; Chen, Peng-Sheng.

In: Journal of Electrocardiology, Vol. 49, No. 6, 01.11.2016, p. 817-823.

Research output: Contribution to journalArticle

Buxton, Alfred E. ; Waks, Jonathan W. ; Shen, Changyu ; Chen, Peng-Sheng. / Risk stratification for sudden cardiac death in North America – current perspectives. In: Journal of Electrocardiology. 2016 ; Vol. 49, No. 6. pp. 817-823.
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