Risperidone and adaptive behavior in children with autism

Susan K. Williams, Lawrence Scahill, Benedetto Vitiello, Michael G. Aman, L. Eugene Arnold, Christopher J. McDougle, James T. McCracken, Elaine Tierney, Louise Ritz, David J. Posey, Naomi Swiezy, Jill Hollway, Pegeen Cronin, Jaswinder Ghuman, Courtney Wheeler, Domenic Cicchetti, Sara Sparrow

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change. Method: Forty-eight children (5 years to 16 years, 5 months) who showed behavioral improvement during acute treatment with risperidone were followed for 6 months and assessed with the Vineland Scales. Results: Raw scores, age-equivalents, and special norm percentile scores all showed significant increases in adaptive behavior in the areas of communication, daily living skills, and socialization (p < .01). During a period of 6 to 8 months, children gained an average of 7.8 age-equivalent months in the area of socialization, a >6% improvement beyond what would be expected based on baseline growth rates. Conclusions: Although limited by the absence of a control group, these results suggest that risperidone may improve adaptive skills in children with autistic disorder accompanied by serious behavioral problems. Vineland age-equivalent scores appear to be most useful in assessing change with treatment over time.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume45
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Risperidone
Psychological Adaptation
Autistic Disorder
Socialization
Research Design
Communication
Control Groups
Therapeutics
Growth
Problem Behavior

Keywords

  • Autism
  • Risperidone
  • Vineland Adaptive Behavior Scales

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Williams, S. K., Scahill, L., Vitiello, B., Aman, M. G., Arnold, L. E., McDougle, C. J., ... Sparrow, S. (2006). Risperidone and adaptive behavior in children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 45(4), 431-439. https://doi.org/10.1097/01.chi.0000196423.80717.32

Risperidone and adaptive behavior in children with autism. / Williams, Susan K.; Scahill, Lawrence; Vitiello, Benedetto; Aman, Michael G.; Arnold, L. Eugene; McDougle, Christopher J.; McCracken, James T.; Tierney, Elaine; Ritz, Louise; Posey, David J.; Swiezy, Naomi; Hollway, Jill; Cronin, Pegeen; Ghuman, Jaswinder; Wheeler, Courtney; Cicchetti, Domenic; Sparrow, Sara.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 45, No. 4, 04.2006, p. 431-439.

Research output: Contribution to journalArticle

Williams, SK, Scahill, L, Vitiello, B, Aman, MG, Arnold, LE, McDougle, CJ, McCracken, JT, Tierney, E, Ritz, L, Posey, DJ, Swiezy, N, Hollway, J, Cronin, P, Ghuman, J, Wheeler, C, Cicchetti, D & Sparrow, S 2006, 'Risperidone and adaptive behavior in children with autism', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 45, no. 4, pp. 431-439. https://doi.org/10.1097/01.chi.0000196423.80717.32
Williams, Susan K. ; Scahill, Lawrence ; Vitiello, Benedetto ; Aman, Michael G. ; Arnold, L. Eugene ; McDougle, Christopher J. ; McCracken, James T. ; Tierney, Elaine ; Ritz, Louise ; Posey, David J. ; Swiezy, Naomi ; Hollway, Jill ; Cronin, Pegeen ; Ghuman, Jaswinder ; Wheeler, Courtney ; Cicchetti, Domenic ; Sparrow, Sara. / Risperidone and adaptive behavior in children with autism. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2006 ; Vol. 45, No. 4. pp. 431-439.
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