RNA interference in cancer

Targeting the anti-apoptotic protein c-FLIP for drug discovery

Travis W. Day, Ahmad Safa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.

Original languageEnglish
Pages (from-to)741-748
Number of pages8
JournalMini-Reviews in Medicinal Chemistry
Volume9
Issue number6
DOIs
StatePublished - 2009

Fingerprint

CASP8 and FADD-Like Apoptosis Regulating Protein
Apoptosis Regulatory Proteins
Drug Discovery
RNA Interference
Gene Silencing
Pharmaceutical Preparations
Neoplasms
Proteins

Keywords

  • Apoptosis
  • Apoptotic pathways
  • c-FLIP
  • Cancer
  • Caspases
  • Drug discovery
  • RNA interference

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

RNA interference in cancer : Targeting the anti-apoptotic protein c-FLIP for drug discovery. / Day, Travis W.; Safa, Ahmad.

In: Mini-Reviews in Medicinal Chemistry, Vol. 9, No. 6, 2009, p. 741-748.

Research output: Contribution to journalArticle

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