RNA interference in cancer: Targeting the anti-apoptotic protein c-FLIP for drug discovery

Travis W. Day, Ahmad R. Safa

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.

Original languageEnglish (US)
Pages (from-to)741-748
Number of pages8
JournalMini-Reviews in Medicinal Chemistry
Volume9
Issue number6
DOIs
StatePublished - 2009

Keywords

  • Apoptosis
  • Apoptotic pathways
  • c-FLIP
  • Cancer
  • Caspases
  • Drug discovery
  • RNA interference

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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