Rodent lines selected for factors affecting alcohol consumption.

T. K. Li, L. Lumeng, W. J. McBride, J. M. Murphy

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The selectively bred alcohol-preferring P and alcohol-nonpreferring NP lines of rats have been used to study the biology of alcohol-seeking behavior. The P rats satisfy all the perceived criteria for an animal model of alcoholism: free-fed animals voluntarily drink alcoholic solutions (10-30% v/v) to intoxication; they acquire metabolic and neuronal tolerance, and develop physical dependence; they work (bar-press) to obtain the alcohol and self-administer ethanol intragastrically. Drinking in the P rats ceases when blood alcohol concentrations (BACs) reach 50-70 mg%, but BACs subsequently rise to as high as 270 mg%. BACs, 15-70 mg%, elicit increased spontaneous motor activity in the P rats, but not in the NP rats. Acute tolerance to a single hypnotic dose of ethanol develops more rapidly and persists many days longer in the P than in the NP rats. These differences in the effects of ethanol may underlie the disparate alcohol drinking behaviors of the P and NP rats. The P rats also exhibit lowered serotonin levels in certain brain regions. Serotonin reuptake inhibitors curtail the alcohol drinking of the P rats, suggesting a role for serotonin in alcohol preference.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalAlcohol and Alcoholism
VolumeSuppl 1
StatePublished - 1987

Fingerprint

Alcohol Drinking
Rodentia
Rats
Alcohols
Ethanol
Blood
Serotonin
Animals
Drinking Behavior
Serotonin Uptake Inhibitors
Hypnotics and Sedatives
Alcoholism
Drinking
Motor Activity
Animal Models
Brain
Blood Alcohol Content

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Li, T. K., Lumeng, L., McBride, W. J., & Murphy, J. M. (1987). Rodent lines selected for factors affecting alcohol consumption. Alcohol and Alcoholism, Suppl 1, 91-96.

Rodent lines selected for factors affecting alcohol consumption. / Li, T. K.; Lumeng, L.; McBride, W. J.; Murphy, J. M.

In: Alcohol and Alcoholism, Vol. Suppl 1, 1987, p. 91-96.

Research output: Contribution to journalArticle

Li, TK, Lumeng, L, McBride, WJ & Murphy, JM 1987, 'Rodent lines selected for factors affecting alcohol consumption.', Alcohol and Alcoholism, vol. Suppl 1, pp. 91-96.
Li TK, Lumeng L, McBride WJ, Murphy JM. Rodent lines selected for factors affecting alcohol consumption. Alcohol and Alcoholism. 1987;Suppl 1:91-96.
Li, T. K. ; Lumeng, L. ; McBride, W. J. ; Murphy, J. M. / Rodent lines selected for factors affecting alcohol consumption. In: Alcohol and Alcoholism. 1987 ; Vol. Suppl 1. pp. 91-96.
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