Rodent models of alcoholic liver disease

Of mice and men

Elizabeth Brandon-Warner, Laura W. Schrum, C. Schmidt, Iain H. McKillop

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Alcoholic liver disease (ALD) is a major cause of acute and chronic liver disease worldwide. The progressive nature of ALD is well described; however, the complex interactions under which these pathologies evolve remain to be fully elucidated. Clinically there are no clear biomarkers or universally accepted, effective treatment strategies for ALD. Experimental models of ALD are an important component in identifying underlying mechanisms of alcohol-induced injury to develop better diagnostic markers, predictors of disease progression, and therapeutic targets to manage, halt, or reverse disease progression. Rodents remain the most accessible model for studying ALD pathology. Effective rodent models must mimic the natural history of ALD while allowing examination of complex interactions between multiple hepatic, and non-hepatic, cell types in the setting of altered metabolic or oxidative/nitrosative stress, inflammatory responses, and sensitivity to cytotoxic stress. Additionally, mode and duration of alcohol delivery influence hepatic response and present unique challenges in understanding disease pathology. This review provides an overview of rodent models of ALD, their strengths and weaknesses relative to human disease states, and provides insight of the potential to develop novel rodent models to simulate the course of human ALD.

Original languageEnglish
Pages (from-to)715-725
Number of pages11
JournalAlcohol
Volume46
Issue number8
DOIs
StatePublished - Dec 2012

Fingerprint

Alcoholic Liver Diseases
alcoholism
Liver
Rodentia
Disease
Pathology
pathology
Disease Progression
Alcohols
alcohol
Liver Diseases
Oxidative Stress
Chronic Disease
Theoretical Models
Biomarkers
Oxidative stress
interaction
Wounds and Injuries
Therapeutics
diagnostic

Keywords

  • Alcohol
  • Cirrhosis
  • Feeding models
  • Fibrosis
  • Hepatocellular carcinoma
  • Humanized mouse
  • Liver disease
  • Steatohepatitis

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neurology
  • Toxicology
  • Health(social science)

Cite this

Rodent models of alcoholic liver disease : Of mice and men. / Brandon-Warner, Elizabeth; Schrum, Laura W.; Schmidt, C.; McKillop, Iain H.

In: Alcohol, Vol. 46, No. 8, 12.2012, p. 715-725.

Research output: Contribution to journalArticle

Brandon-Warner, E, Schrum, LW, Schmidt, C & McKillop, IH 2012, 'Rodent models of alcoholic liver disease: Of mice and men', Alcohol, vol. 46, no. 8, pp. 715-725. https://doi.org/10.1016/j.alcohol.2012.08.004
Brandon-Warner, Elizabeth ; Schrum, Laura W. ; Schmidt, C. ; McKillop, Iain H. / Rodent models of alcoholic liver disease : Of mice and men. In: Alcohol. 2012 ; Vol. 46, No. 8. pp. 715-725.
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