Role for targeted resection in the multidisciplinary treatment of metastatic gastrointestinal stromal tumor

Bradford J. Kim, Daniel P. Milgrom, Cyrus Feizpour, Joshua K. Kays, Leonidas Koniaris

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The management of advanced gastrointestinal stromal tumors (GISTs) has evolved in the modern era due to the discovery of c-kit mutations and the development of tyrosine kinase inhibitors (TKIs). Until the advent of TKIs such as imatinib, the median survival reported for patients with advanced GIST was 19 months. Although surgery is the treatment of choice for resectable primary GIST, its role in cases of recurrence and metastasis remains to be unclear. This review outlines the potential beneficial role of repeat surgical resection in the multidisciplinary treatment of advanced GIST in the era of TKIs.

Original languageEnglish (US)
Article number26
JournalTranslational Gastroenterology and Hepatology
Volume4
Issue numberApril
DOIs
StatePublished - Apr 1 2019

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Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Therapeutics
Neoplasm Metastasis
Recurrence
Mutation
Survival

Keywords

  • KIT
  • PDGFR
  • Resection

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Role for targeted resection in the multidisciplinary treatment of metastatic gastrointestinal stromal tumor. / Kim, Bradford J.; Milgrom, Daniel P.; Feizpour, Cyrus; Kays, Joshua K.; Koniaris, Leonidas.

In: Translational Gastroenterology and Hepatology, Vol. 4, No. April, 26, 01.04.2019.

Research output: Contribution to journalReview article

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