Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice

Min You, Robert Considine, Teresa C. Leone, Daniel P. Kelly, David Crabb

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

The protective effect of dietary saturated fatty acids against the development of alcoholic liver disease has long been known, but the underlying mechanism is not completely understood. We examined the involvement of the adipocyte hormone adiponectin. Circulating adiponectin levels were significantly elevated by chronic ethanol administration to mice consuming a diet high in saturated fat. The increase in circulating adiponectin was associated with the activation a set of hepatic signaling pathways mediated through AMP-activated protein kinase, PPAR-α, and PPAR-γ coactivator α, which in turn led to markedly increased rates of fatty acid oxidation, prevention of hepatic steatosis, and alleviation of liver enzyme changes. Furthermore, treatment of rat 3T3-L1 adipocytes with saturated fatty acids (palmitic or stearic acids) in the presence of ethanol increased secretion of adiponectin and enhanced activity of a mouse adiponectin promoter. In conclusion, the protective action of saturated fat against the development of alcoholic fatty liver in mice is partially mediated through induction of adiponectin. The present findings suggest a novel paradigm for dietary fatty acids in the pathogenesis of alcoholic liver disease and provide a promising therapeutic strategy-nutritional modulation of adiponectin-in treating human alcoholic fatty liver disease.

Original languageEnglish
Pages (from-to)568-577
Number of pages10
JournalHepatology
Volume42
Issue number3
DOIs
StatePublished - Sep 2005

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Alcoholic Fatty Liver
Dietary Fats
Adiponectin
Alcoholic Liver Diseases
Fatty Acids
Peroxisome Proliferator-Activated Receptors
Adipocytes
Ethanol
Fats
Stearic Acids
AMP-Activated Protein Kinases
Liver
Fatty Liver
Hormones
Diet
Enzymes

ASJC Scopus subject areas

  • Hepatology

Cite this

Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. / You, Min; Considine, Robert; Leone, Teresa C.; Kelly, Daniel P.; Crabb, David.

In: Hepatology, Vol. 42, No. 3, 09.2005, p. 568-577.

Research output: Contribution to journalArticle

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