Role of airway smooth muscle mechanical properties in the regulation of airway caliber

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The changes in lung volume that occur during normal tidal breathing and with intermittent deep inspirations play an important role in the maintenance of normal low airway responsiveness and in dilating constricted airways. The mechanical responses of airway smooth muscle in response to stretch underlie many of the physiologic effects of lung volume changes on airway caliber and airway responsiveness in vivo in normal humans and experimental animals. These properties have their basis in dynamic cytoskeletal processes that enable the airway smooth muscle cell to modify its shape and the organization of its cytoskeletal and contractile filaments in response to external forces that are imposed upon the airway smooth muscle tissue. Transmembrane integrin proteins sense mechanical forces imposed on airway smooth muscle tissues and transduce mechanical signals to macromolecular protein adhesion complexes (adhesomes) associated with the cytoskeletal domain of integrin proteins. Adhesome proteins mediate signals to cytoskeletal effector proteins that regulate cytoskeletal organization resulting in the remodeling of contractile and cytoskeletal filaments and their organization within the cell. Adhesome complexes also mediate signals to the nucleus that regulate changes in the phenotype and function of the airway smooth muscle cell. Mechanical stimuli imposed during breathing must be considered a primary physiologic mechanism for regulating the physiologic and pathophysiologic properties of airway smooth muscle.

Original languageEnglish (US)
Title of host publicationMechanics of Breathing: New Insights from New Technologies: Second Edition
PublisherSpringer-Verlag Italia s.r.l.
Pages53-64
Number of pages12
ISBN (Print)9788847056473, 8847056462, 9788847056466
DOIs
StatePublished - Jan 1 2014

Fingerprint

Smooth Muscle
Cytoskeleton
Integrins
Smooth Muscle Myocytes
Respiration
Multiprotein Complexes
Muscles
Lung
Cytoskeletal Proteins
Proteins
Maintenance
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gunst, S. (2014). Role of airway smooth muscle mechanical properties in the regulation of airway caliber. In Mechanics of Breathing: New Insights from New Technologies: Second Edition (pp. 53-64). Springer-Verlag Italia s.r.l.. https://doi.org/10.1007/978-88-470-5647-3_5

Role of airway smooth muscle mechanical properties in the regulation of airway caliber. / Gunst, Susan.

Mechanics of Breathing: New Insights from New Technologies: Second Edition. Springer-Verlag Italia s.r.l., 2014. p. 53-64.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gunst, S 2014, Role of airway smooth muscle mechanical properties in the regulation of airway caliber. in Mechanics of Breathing: New Insights from New Technologies: Second Edition. Springer-Verlag Italia s.r.l., pp. 53-64. https://doi.org/10.1007/978-88-470-5647-3_5
Gunst S. Role of airway smooth muscle mechanical properties in the regulation of airway caliber. In Mechanics of Breathing: New Insights from New Technologies: Second Edition. Springer-Verlag Italia s.r.l. 2014. p. 53-64 https://doi.org/10.1007/978-88-470-5647-3_5
Gunst, Susan. / Role of airway smooth muscle mechanical properties in the regulation of airway caliber. Mechanics of Breathing: New Insights from New Technologies: Second Edition. Springer-Verlag Italia s.r.l., 2014. pp. 53-64
@inbook{72c1cac4d5234a0d9e331fc02e6590a3,
title = "Role of airway smooth muscle mechanical properties in the regulation of airway caliber",
abstract = "The changes in lung volume that occur during normal tidal breathing and with intermittent deep inspirations play an important role in the maintenance of normal low airway responsiveness and in dilating constricted airways. The mechanical responses of airway smooth muscle in response to stretch underlie many of the physiologic effects of lung volume changes on airway caliber and airway responsiveness in vivo in normal humans and experimental animals. These properties have their basis in dynamic cytoskeletal processes that enable the airway smooth muscle cell to modify its shape and the organization of its cytoskeletal and contractile filaments in response to external forces that are imposed upon the airway smooth muscle tissue. Transmembrane integrin proteins sense mechanical forces imposed on airway smooth muscle tissues and transduce mechanical signals to macromolecular protein adhesion complexes (adhesomes) associated with the cytoskeletal domain of integrin proteins. Adhesome proteins mediate signals to cytoskeletal effector proteins that regulate cytoskeletal organization resulting in the remodeling of contractile and cytoskeletal filaments and their organization within the cell. Adhesome complexes also mediate signals to the nucleus that regulate changes in the phenotype and function of the airway smooth muscle cell. Mechanical stimuli imposed during breathing must be considered a primary physiologic mechanism for regulating the physiologic and pathophysiologic properties of airway smooth muscle.",
author = "Susan Gunst",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-88-470-5647-3_5",
language = "English (US)",
isbn = "9788847056473",
pages = "53--64",
booktitle = "Mechanics of Breathing: New Insights from New Technologies: Second Edition",
publisher = "Springer-Verlag Italia s.r.l.",

}

TY - CHAP

T1 - Role of airway smooth muscle mechanical properties in the regulation of airway caliber

AU - Gunst, Susan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The changes in lung volume that occur during normal tidal breathing and with intermittent deep inspirations play an important role in the maintenance of normal low airway responsiveness and in dilating constricted airways. The mechanical responses of airway smooth muscle in response to stretch underlie many of the physiologic effects of lung volume changes on airway caliber and airway responsiveness in vivo in normal humans and experimental animals. These properties have their basis in dynamic cytoskeletal processes that enable the airway smooth muscle cell to modify its shape and the organization of its cytoskeletal and contractile filaments in response to external forces that are imposed upon the airway smooth muscle tissue. Transmembrane integrin proteins sense mechanical forces imposed on airway smooth muscle tissues and transduce mechanical signals to macromolecular protein adhesion complexes (adhesomes) associated with the cytoskeletal domain of integrin proteins. Adhesome proteins mediate signals to cytoskeletal effector proteins that regulate cytoskeletal organization resulting in the remodeling of contractile and cytoskeletal filaments and their organization within the cell. Adhesome complexes also mediate signals to the nucleus that regulate changes in the phenotype and function of the airway smooth muscle cell. Mechanical stimuli imposed during breathing must be considered a primary physiologic mechanism for regulating the physiologic and pathophysiologic properties of airway smooth muscle.

AB - The changes in lung volume that occur during normal tidal breathing and with intermittent deep inspirations play an important role in the maintenance of normal low airway responsiveness and in dilating constricted airways. The mechanical responses of airway smooth muscle in response to stretch underlie many of the physiologic effects of lung volume changes on airway caliber and airway responsiveness in vivo in normal humans and experimental animals. These properties have their basis in dynamic cytoskeletal processes that enable the airway smooth muscle cell to modify its shape and the organization of its cytoskeletal and contractile filaments in response to external forces that are imposed upon the airway smooth muscle tissue. Transmembrane integrin proteins sense mechanical forces imposed on airway smooth muscle tissues and transduce mechanical signals to macromolecular protein adhesion complexes (adhesomes) associated with the cytoskeletal domain of integrin proteins. Adhesome proteins mediate signals to cytoskeletal effector proteins that regulate cytoskeletal organization resulting in the remodeling of contractile and cytoskeletal filaments and their organization within the cell. Adhesome complexes also mediate signals to the nucleus that regulate changes in the phenotype and function of the airway smooth muscle cell. Mechanical stimuli imposed during breathing must be considered a primary physiologic mechanism for regulating the physiologic and pathophysiologic properties of airway smooth muscle.

UR - http://www.scopus.com/inward/record.url?scp=84930986659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930986659&partnerID=8YFLogxK

U2 - 10.1007/978-88-470-5647-3_5

DO - 10.1007/978-88-470-5647-3_5

M3 - Chapter

AN - SCOPUS:84930986659

SN - 9788847056473

SN - 8847056462

SN - 9788847056466

SP - 53

EP - 64

BT - Mechanics of Breathing: New Insights from New Technologies: Second Edition

PB - Springer-Verlag Italia s.r.l.

ER -