Role of atrial substrate and spatiotemporal organization in atrial fibrillation

Albert M. Kim, Jeffrey E. Olgin, Thomas H. Everett IV

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Atrial fibrillation (AF) is a heterogeneous disease that presents in a wide range of clinical scenarios. Correspondingly, a diverse array of large animal models has developed for the study of AF. Different atrial substrate exists in these models, and quantitative analysis of the AF that develops in each case reveals unique characteristics. This article reviews the defining properties of several prominent AF animal models, with a focus on how spatiotemporal organization can discriminate between AF substrates. It addresses how spatiotemporal assessments have been extended to human AF and discusses the insights gained from these new analyses.

Original languageEnglish (US)
Pages (from-to)S1-S7
JournalHeart Rhythm
Issue number8 SUPPL.
StatePublished - Aug 1 2009
Externally publishedYes


  • Animal models
  • Atrial fibrillation
  • Dominant frequency
  • Optical mapping
  • Spatiotemporal organization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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