Role of bone disease in the pathogenesis of multiple myeloma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MM cells produce factors which stimulate bone resorption and suppress new bone formation. In addition, MMBD has a major role in pathogenesis of MM. OCL can both stimulate MM cell growth and tumor-associated angiogenesis which both enhance growth of tumor cells and chemoresistance. Further, OCL release growth factors from the bone marrow microenvironment, which amplify the growth effects of other growth factors produced by cells in the marrow microenvironment. OCL can also produce growth factors that directly stimulate MM cell growth. The recent results showing that mature OB can suppress MM cell growth suggests that suppression of OB differentiation in MM plays a key role in tumor progression, and if it can be reversed, and OB differentiation induced in patients, this would further suppress tumor growth and improve both bone quality and the quality of life of the patients. The availability of new anabolic agents that are safe for use on MM patients and stimulate new bone formation while not stimulating MM cell growth may reverse the devastating effects of MMBD. Thus, identification of agents that target both MM cells and the microenvironment should provide new therapeutic modalities that suppress or eradicate the tumor and restore bone health in patients with MM.

Original languageEnglish (US)
Title of host publicationGenetic and Molecular Epidemiology of Multiple Myeloma
PublisherSpringer New York
Pages97-120
Number of pages24
Volume9781461446606
ISBN (Electronic)9781461446606
ISBN (Print)1461446597, 9781461446590
DOIs
StatePublished - May 1 2013

Keywords

  • Bone disease
  • Bone formation
  • Cytokines
  • Marrow -microenvironment
  • Multiple myeloma
  • Osteoblast
  • Osteoclast
  • Pathogenesis
  • RANK
  • RANKL
  • Skeleton-related event
  • Tumor growth

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Roodman, G. D. (2013). Role of bone disease in the pathogenesis of multiple myeloma. In Genetic and Molecular Epidemiology of Multiple Myeloma (Vol. 9781461446606, pp. 97-120). Springer New York. https://doi.org/10.1007/978-1-4614-4660-6_6